Antimicrobial use among paediatric inpatients at hospital sites within the Canadian Nosocomial Infection Surveillance Program, 2017/2018

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dc.contributor.authorRudnick, Wallis
dc.contributor.authorConly, John
dc.contributor.authorThirion, Daniel J. G.
dc.contributor.authorChoi, Kelly
dc.contributor.authorPelude, Linda
dc.contributor.authorCayen, Joelle
dc.contributor.authorBautista, John
dc.contributor.authorBeique, Lizanne
dc.contributor.authorComeau, Jeannette L.
dc.contributor.authorDalton, Bruce
dc.contributor.authorDelport, Johan
dc.contributor.authorDhami, Rita
dc.contributor.authorEmbree, Joanne
dc.contributor.authorÉmond, Yannick
dc.contributor.authorEvans, Gerald
dc.contributor.authorFrenette, Charles
dc.contributor.authorFryters, Susan
dc.contributor.authorHappe, Jennifer
dc.contributor.authorKatz, Kevin
dc.contributor.authorKibsey, Pamela
dc.contributor.authorLangley, Joanne M.
dc.contributor.authorLee, Bonita E.
dc.contributor.authorLefebvre, Marie-Astrid
dc.contributor.authorLeis, Jerome A.
dc.contributor.authorMcGeer, Allison
dc.contributor.authorMcKenna, Susan
dc.contributor.authorNeville, Heather L.
dc.contributor.authorSlayter, Kathryn
dc.contributor.authorSuh, Kathryn N.
dc.contributor.authorTse-Chang, Alena
dc.contributor.authorWeiss, Karl
dc.contributor.authorScience, Michelle
dc.date.accessioned2023-04-23T00:03:32Z
dc.date.available2023-04-23T00:03:32Z
dc.date.issued2023-04-18
dc.date.updated2023-04-23T00:03:32Z
dc.description.abstractAbstract Background Antimicrobial resistance threatens the ability to successfully prevent and treat infections. While hospital benchmarks regarding antimicrobial use (AMU) have been well documented among adult populations, there is less information from among paediatric inpatients. This study presents benchmark rates of antimicrobial use (AMU) for paediatric inpatients in nine Canadian acute-care hospitals. Methods Acute-care hospitals participating in the Canadian Nosocomial Infection Surveillance Program submitted annual AMU data from paediatric inpatients from 2017 and 2018. All systemic antimicrobials were included. Data were available for neonatal intensive care units (NICUs), pediatric ICUs (PICUs), and non-ICU wards. Data were analyzed using days of therapy (DOT) per 1000 patient days (DOT/1000pd). Results Nine hospitals provided paediatric AMU data. Data from seven NICU and PICU wards were included. Overall AMU was 481 (95% CI 409–554) DOT/1000pd. There was high variability in AMU between hospitals. AMU was higher on PICU wards (784 DOT/1000pd) than on non-ICU (494 DOT/1000pd) or NICU wards (333 DOT/1000pd). On non-ICU wards, the antimicrobials with the highest use were cefazolin (66 DOT/1000pd), ceftriaxone (59 DOT/1000pd) and piperacillin-tazobactam (48 DOT/1000pd). On PICU wards, the antimicrobials with the highest use were ceftriaxone (115 DOT/1000pd), piperacillin-tazobactam (115 DOT/1000pd), and cefazolin (111 DOT/1000pd). On NICU wards, the antimicrobials with the highest use were ampicillin (102 DOT/1000pd), gentamicin/tobramycin (78 DOT/1000pd), and cefotaxime (38 DOT/1000pd). Conclusions This study represents the largest collection of antimicrobial use data among hospitalized paediatric inpatients in Canada to date. In 2017/2018, overall AMU was 481 DOT/1000pd. National surveillance of AMU among paediatric inpatients is necessary for establishing benchmarks and informing antimicrobial stewardship efforts.
dc.identifier.citationAntimicrobial Resistance & Infection Control. 2023 Apr 18;12(1):35
dc.identifier.urihttps://doi.org/10.1186/s13756-023-01219-x
dc.identifier.urihttp://hdl.handle.net/1880/116099
dc.identifier.urihttps://dx.doi.org/10.11575/PRISM/dspace/40945
dc.language.rfc3066en
dc.rights.holderThe Author(s)
dc.titleAntimicrobial use among paediatric inpatients at hospital sites within the Canadian Nosocomial Infection Surveillance Program, 2017/2018
dc.typeJournal Article
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