D1 receptors physically interact with N-type calcium channels to regulate channel distribution and dendritic calcium entry

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dc.contributor.authorKisilevsky, Alexandra E.
dc.contributor.authorMulligan, Sean J.
dc.contributor.authorAltier, Christophe
dc.contributor.authorIftinca, Mircea C.
dc.contributor.authorVarela, Diego L.
dc.contributor.authorTai, Chao
dc.contributor.authorChen, Lina
dc.contributor.authorHameed, Shahid
dc.contributor.authorHamid, Jawed
dc.contributor.authorMacVicar, Brian Archibald
dc.contributor.authorZamponi, Gerald W.
dc.date.accessioned2018-06-06T17:20:10Z
dc.date.available2018-06-06T17:20:10Z
dc.date.issued2008-05-22
dc.description.abstractDopamine signaling through D1 receptors in the prefrontal cortex (PFC) plays a critical role in the maintenance of higher cognitive functions, such as working memory. At the cellular level, these functions are predicated to involve alterations in neuronal calcium levels. The dendrites of PFC neurons express D1 receptors and N-type calcium channels, yet little information exists regarding their coupling. Here, we show that D1 receptors potently inhibit N-type channels in dendrites of rat PFC neurons. Using coimmunoprecipitation, we demonstrate the existence of a D1 receptor-N-type channel signaling complex in this region, and we provide evidence for a direct receptor-channel interaction. Finally, we demonstrate the importance of this complex to receptor-channel colocalization in heterologous systems and in PFC neurons. Our data indicate that the N-type calcium channel is an important physiological target of D1 receptors and reveal a mechanism for D1 receptor-mediated regulation of cognitive function in the PFC.en_US
dc.identifier.citationKisilevsky, A. E., Mulligan, S. J., Altier, C., Iftinca, M. C., Varela, D., Tai, C., … Zamponi, G. W. (2008). D1 Receptors Physically Interact with N-Type Calcium Channels to Regulate Channel Distribution and Dendritic Calcium Entry. Neuron, 58(4), 557–570. https://doi.org/10.1016/j.neuron.2008.03.002en_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.neuron.2008.03.002en_US
dc.identifier.issn0896-6273
dc.identifier.urihttp://hdl.handle.net/1880/106725
dc.identifier.urihttps://doi.org/10.11575/PRISM/43797
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.publisher.departmentPhysiology & Pharmacologyen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.publisher.policyhttps://www.cell.com/neuron/authorsen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.titleD1 receptors physically interact with N-type calcium channels to regulate channel distribution and dendritic calcium entryen_US
dc.typejournal articleen_US
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