Predicting Thrombus Formation in Patients with Internal Carotid Artery Webs

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atmire.migration.oldid5799
dc.contributor.advisorMitha, Alim P.
dc.contributor.advisorDi Martino, Elena
dc.contributor.authorAli, Syedah Salwa
dc.contributor.committeememberTyberg, John V.
dc.contributor.committeememberEgberts, Philip
dc.contributor.committeememberWood, David
dc.contributor.committeememberNatale, Giovanniantonio
dc.date.accessioned2017-07-18T20:08:41Z
dc.date.available2017-07-18T20:08:41Z
dc.date.issued2017
dc.date.submitted2017en
dc.description.abstractCarotid webs are fibro-intimal growths affecting the internal carotid artery but are pathologically different from common atherosclerotic plaques. They cause moderate stenosis and are difficult to diagnose. However, if treated, patients present themselves again with recurrent ischemic strokes due to thrombus formation distal to the stenosis. Lack of knowledge urged the need to conduct hemodynamic analysis. This is the first study to quantify hemodynamic changes in the carotid web region. We conducted transient analysis on 3 symptomatic stroke patients with carotid webs. Carotid web region in each of the 3 carotid arteries with web was calculated with high OSI levels (0.3 approx.), low TAWSS values (less than 0.4Pa) and high RRT values. We also visualized recirculating flow behind the web during deceleration phases of cardiac cycle. All these factors reveal that carotid webs disturb blood flow patterns to cause blood stagnation, recirculation and thrombus formation to cause stroke.en_US
dc.identifier.citationAli, S. S. (2017). Predicting Thrombus Formation in Patients with Internal Carotid Artery Webs (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27407en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/27407
dc.identifier.urihttp://hdl.handle.net/11023/3969
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectEducation--Health
dc.subjectAnatomy
dc.subjectNeuroscience
dc.subjectBiophysics--Medical
dc.subjectFluid and Plasma
dc.subjectEngineering--Biomedical
dc.subjectPsychology--Clinical
dc.subject.otherExternal Carotid Artery (ECA)
dc.subject.otherWebs
dc.subject.otherStroke
dc.subject.otherComputational Fluid Dynamics (CFD)
dc.subject.otherInternal Carotid Artery (ICA)
dc.subject.otherUser Defined Function (UDF)
dc.subject.otherTime Averaged Wall Shear Stress (TAWSS)
dc.subject.otherWall Shear Stress (WSS)
dc.subject.otherCarotid Artery
dc.subject.otherHemodynamic Wall descriptors (HWD)
dc.subject.otherOscillatory Shear Index (OSI)
dc.subject.otherRelative Residence Time (RRT)
dc.titlePredicting Thrombus Formation in Patients with Internal Carotid Artery Webs
dc.typemaster thesis
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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