A Systematic Review and Meta-Analysis of Outcomes for Type 1 Diabetes after Bariatric Surgery
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2016-06-08
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Abstract
Background. The utility of bariatric surgery in type 1 diabetes remains controversial. The aim of the present study is to evaluate glycemic control outcomes in obese patients with type 1 diabetes after bariatric surgery. Methods. A comprehensive search of electronic databases was completed. Inclusion criteria included human adult subjects with BMI ≥35 kg/m2 and a confirmed diagnosis of type 1 diabetes who underwent a bariatric surgical procedure. Results. Thirteen primary studies (86 patients) were included. Subjects had a mean age of years with a mean BMI of kg/m2. There was a marked reduction in BMI postoperatively at 12 months and at study endpoint to kg/m2 () and kg/m2 (), respectively. Preoperative weighted mean total daily insulin requirement was IU/d, which decreased significantly to IU/d () and IU/d () at 12 months and at study endpoint, respectively. An improvement in HbA1c was also seen from % preoperatively to % () and % () at 12 months and at study endpoint, respectively. Conclusion. Bariatric surgery in patients with type 1 diabetes leads to significant reductions in BMI and improvements in glycemic control.
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Alexandra Chow, Noah J. Switzer, Jerry Dang, et al., “A Systematic Review and Meta-Analysis of Outcomes for Type 1 Diabetes after Bariatric Surgery,” Journal of Obesity, vol. 2016, Article ID 6170719, 7 pages, 2016. doi:10.1155/2016/6170719