Regulation of calcium channels by RGK proteins
Date
2010-12-01
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Publisher
Taylor and Francis
Abstract
The RGK family of proteins, small GTPases of the Ras superfamily, are known to regulate calcium currents. It is commonly thought that this is due to an interaction with the CavĪ² subunit, however, the mechanism of this inhibition is unclear. There have been conflicting reports of whether RGK proteins can affect channel trafficking or whether they reduce calcium currents by interacting with channels at the membrane. In the last year, several studies have emerged which explore the intricacies of RGK protein interaction with the channel itself and the importance of the CavĪ² subunit for this interaction, in addition to providing some tantalizing suggestions for the mechanism by which RGK proteins reduce or eliminate calcium currents. In this review, we present an overview of these recent advances and suggest a model that may synthesize these latest works.
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Citation
Flynn, R., & Zamponi, G. (2010). Calcium channel regulation by RGK proteins. Channels. Taylor and Francis Inc. https://doi.org/10.4161/chan.4.6.12865