Sildenafil Treatment of Primary Pulmonary Hypertension
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2003-01-01
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Abstract
A 37-year-old woman with primary pulmonary hypertension and worsening symptomatology underwent pulmonary artery (PA) catheterization and vasodilator trials. Oxygen had no effect, but 10 parts/million of nitric oxide reduced mean PA (PAm) pressure by 20%. Prostacyclin infusion at 8 ng/kg/min decreased the PAm pressure by 11%, but further dose increases were limited by systemic hypotension. Sildenafil in doses of 25 mg or higher resulted in an average decrease of 14% in PAm pressure. Sildenafil is a potentially useful treatment option for patients with primary pulmonary hypertension, and further investigation is warranted.
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Kevin B Laupland, Doug Helmersen, David A Zygun, and Sidney M Viner, “Sildenafil Treatment of Primary Pulmonary Hypertension,” Canadian Respiratory Journal, vol. 10, no. 1, pp. 48-50, 2003. doi:10.1155/2003/612905