In Vivo MR Imaging of Tumor-Associated Macrophages: The Next Frontier in Cancer Imaging

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dc.contributor.authorYang, Runze
dc.contributor.authorSarkar, Susobhan
dc.contributor.authorYong, Voon Wee E.
dc.contributor.authorDunn, Jeff F.
dc.date.accessioned2018-10-25T16:14:10Z
dc.date.available2018-10-25T16:14:10Z
dc.date.issued2018-03-22
dc.description.abstractThere is a complex interaction between cancer and the immune system. Tumor-associated macrophages (TAMs) can be subverted by the cancer to adopt a pro-tumor phenotype to aid tumor growth. These anti-inflammatory, pro-tumor TAMs have been shown to contribute to a worsened outcome in several different types of cancer. Various strategies aimed at combating the pro-tumor TAMs have been developed. Several therapies, such as oncolytic viral therapy and high-intensity focused ultrasound, have been shown to stimulate TAMs and suppress tumor growth. Targeting TAMs is a promising way to combat cancer, but sensitive imaging methods that are capable of detecting these therapeutic responses are needed. A promising idea is to use imaging contrast agents to label TAMs to determine their relative number and location within, and around the tumor. This can provide information about the efficacy of TAM depletion therapies, as well as macrophage-stimulating therapies. In this review, we describe various in vivo MRI methods capable of tracking TAMs, and conclude with a short section on tracking TAMs in patients.en_US
dc.description.grantingagencyAlberta Innovates - Research Granten_US
dc.description.grantingagencyAlberta Cancer Foundation - Research Granten_US
dc.description.grantingagencyBrain Canada - Research Granten_US
dc.identifier.citationYang, R., Sarkar, S., Yong, V. W. E., & Dunn, J. F. (2018). In Vivo MR Imaging of Tumor-Associated Macrophages: The Next Frontier in Cancer Imaging. "Magnetic Resonance Insights", 11, 1-8. https://doi/org./10.1177/1178623X18771974en_US
dc.identifier.doi10.1177/1178623X18771974en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33895
dc.identifier.issn1178-623X
dc.identifier.urihttp://hdl.handle.net/1880/108914
dc.language.isoenen_US
dc.publisherSAGE Publicationsen_US
dc.publisher.departmentRadiologyen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.policyhttp://www.sherpa.ac.uk/romeo/issn/1178-623X/en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0en_US
dc.subjectTumor-associated macrophageen_US
dc.subjectcanceren_US
dc.subjectimagingen_US
dc.subjectcell trackingen_US
dc.subjectmagnetic resonance imagingen_US
dc.titleIn Vivo MR Imaging of Tumor-Associated Macrophages: The Next Frontier in Cancer Imagingen_US
dc.typejournal articleen_US
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