Investigating Bone Remodelling in Knee Osteoarthritis using HR-pQCT Imaging

Kaketsis, Daphne Angelique

Investigating Bone Remodelling in Knee Osteoarthritis using HR-pQCT Imaging

dc.contributor.advisor	Manske, Sarah Lynn
dc.contributor.author	Kaketsis, Daphne Angelique
dc.contributor.committeemember	Bertram, John Edward Arthur
dc.contributor.committeemember	Boyd, Steven Kyle
dc.contributor.committeemember	Edwards, William Brent
dc.contributor.committeemember	Zimmermann, Elizabeth Ann
dc.date	2023-11
dc.date.accessioned	2023-05-19T15:57:34Z
dc.date.available	2023-05-19T15:57:34Z
dc.date.issued	2023-05-12
dc.description.abstract	Osteoarthritis (OA) is the most common type of arthritis and a significant cause of disability worldwide. With an aging population in Canada, the prevalence and burden of OA is expected to increase. Knee OA is the most common form of OA, comprising upwards of 30% of cases. Early-stage OA can be difficult to diagnose, as often times pain and radiographical evidence do not align; however, abnormal subchondral bone remodelling has been considered to have an important role in OA pathogenesis, and some propose that it could offer a target for OA treatment. Clinically, measures of bone remodelling have been performed on iliac crest bone biopsies that are invasive and do not capture local changes. Recently, high resolution peripheral quantitative computed tomography (HR-pQCT) has been utilized in several different ways to analyse bone dynamics, or how the bone changes over time. These measurements are sensitive to several factors such as noise and motion but have yet to be validated in humans. The purpose of this study was to determine whether HR-pQCT can be used to measure longitudinal bone remodelling at the knee in humans with knee OA. Longitudinal bone remodelling results were compared to same-day rescan images to conduct a repeatability analysis. There were no significant differences between longitudinal and rescan results for bone formation (p = 0.47), bone resorption (p = 0.12), or net bone remodelling (p = 0.748). Additionally, the least detectable changes measured were 10.88% for bone formation, 10.53% for bone resorption, and 4.05% for net bone remodelling. These results indicate that with the current imaging procedures, there is too much error in the scans and processing pipeline to measure bone remodelling longitudinally in-vivo in the knee.
dc.identifier.citation	Kaketsis, D. A. (2023). Investigating bone remodelling in knee osteoarthritis using HR-pQCT imaging (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.
dc.identifier.uri	https://hdl.handle.net/1880/116554
dc.identifier.uri	https://dx.doi.org/10.11575/PRISM/dspace/41397
dc.language.iso	en
dc.publisher.faculty	Graduate Studies
dc.publisher.institution	University of Calgary
dc.rights	University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subject	High Resolution Peripheral Quantitative Computed Tomography
dc.subject	Bone Remodelling
dc.subject	Bone Marrow Lesion
dc.subject	Knee Osteoarthritis
dc.subject.classification	Engineering--Biomedical
dc.subject.classification	Health Care Management
dc.title	Investigating Bone Remodelling in Knee Osteoarthritis using HR-pQCT Imaging
dc.type	master thesis
thesis.degree.discipline	Engineering – Biomedical
thesis.degree.grantor	University of Calgary
thesis.degree.name	Master of Science (MSc)
ucalgary.thesis.accesssetbystudent	I do not require a thesis withhold – my thesis will have open access and can be viewed and downloaded publicly as soon as possible.