Nitric oxide as a mediator of gastrointestinal mucosal injury?—Say it ain't so

dc.contributor.authorKubes, Paul
dc.contributor.authorWallace, John L.
dc.date.accessioned2018-09-27T12:30:44Z
dc.date.available2018-09-27T12:30:44Z
dc.date.issued1995-01-01
dc.date.updated2018-09-27T12:30:44Z
dc.description.abstractNitric oxide has been suggested as a contributor to tissue injury in various experimental models of gastrointestinal inflammation. However, there is overwhelming evidence that nitric oxide is one of the most important mediators of mucosal defence, influencing such factors as mucus secretion, mucosal blood flow, ulcer repair and the activity of a variety of mucosal immunocytes. Nitric oxide has the capacity to down-regulate inflammatory responses in the gastrointestinal tract, to scavenge various free radical species and to protect the mucosa from injury induced by topical irritants. Moreover, questions can be raised regarding the evidence purported to support a role for nitric oxide in producing tissue injury. In this review, we provide an overview of the evidence supporting a role for nitric oxide in protecting the gastrointestinal tract from injury.
dc.description.versionPeer Reviewed
dc.identifier.citationPaul Kubes and John L. Wallace, “Nitric oxide as a mediator of gastrointestinal mucosal injury?—Say it ain't so,” Mediators of Inflammation, vol. 4, no. 6, pp. 397-405, 1995. doi:10.1155/S0962935195000640
dc.identifier.doihttps://doi.org/10.1155/S0962935195000640
dc.identifier.urihttp://hdl.handle.net/1880/108649
dc.identifier.urihttps://doi.org/10.11575/PRISM/45227
dc.language.rfc3066en
dc.rights.holderCopyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleNitric oxide as a mediator of gastrointestinal mucosal injury?—Say it ain't so
dc.typeJournal Article
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
MI.1995.107947.pdf
Size:
2.09 MB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
0 B
Format:
Item-specific license agreed upon to submission
Description: