Human Rhinovirus Infection of Airway Epithelial Cells Modulates Airway Smooth Muscle Migration

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atmire.migration.oldid3939
dc.contributor.advisorLeigh, Richard
dc.contributor.advisorProud, David
dc.contributor.authorShariff, Sami
dc.contributor.committeememberKubes, Paul
dc.contributor.committeememberGiembycz, Mark
dc.date.accessioned2015-12-22T21:03:03Z
dc.date.available2015-12-22T21:03:03Z
dc.date.issued2015-12-22
dc.date.submitted2015en
dc.description.abstractThe traditional paradigm of airway remodeling in asthma has held that remodeling occurs after many years of chronic inflammation. However, studies have confirmed that remodeling changes are observed in children even before the clinical diagnosis of asthma is established. There is now robust evidence to indicate that children with recurrent human rhinovirus (HRV)-induced wheezing episodes are at significantly increased risk of developing subsequent asthma. A feature of airway remodeling is increased airway smooth muscle (ASM) mass with a greater proximity of the ASM to the subepithelial region, and we interrogated the hypothesis that HRV-induced alterations of airway epithelial cell biology might regulate ASM migration. We demonstrated that ASM chemotaxis is GPCR dependent, can be regulated by cAMP and is dependent upon CCL5 release by the epithelium post-HRV infection. These observations substantiate the growing body of evidence that links HRV infections to the subsequent development of asthma.en_US
dc.identifier.citationShariff, S. (2015). Human Rhinovirus Infection of Airway Epithelial Cells Modulates Airway Smooth Muscle Migration (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26398en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/26398
dc.identifier.urihttp://hdl.handle.net/11023/2699
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectBiology--Cell
dc.subjectMicrobiology
dc.subjectBiology--Molecular
dc.subject.classificationAsthmaen_US
dc.subject.classificationHRVen_US
dc.subject.classificationCommon Colden_US
dc.subject.classificationchemotaxisen_US
dc.subject.classificationMigrationen_US
dc.subject.classificationAirway smooth muscleen_US
dc.subject.classificationEpitheliumen_US
dc.subject.classificationAirway Remodelingen_US
dc.titleHuman Rhinovirus Infection of Airway Epithelial Cells Modulates Airway Smooth Muscle Migration
dc.typemaster thesis
thesis.degree.disciplineCardiovascular & Respiratory Sciences
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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