Microelectrodes for Neural Stimulation: Effects of Geometry

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atmire.migration.oldid1595
dc.contributor.advisorWestwick, David
dc.contributor.advisorDalton, Colin
dc.contributor.authorGhazavi Khorasgani, Atefeh
dc.date.accessioned2013-10-08T16:34:45Z
dc.date.available2013-11-12T08:00:20Z
dc.date.issued2013-10-08
dc.date.submitted2013en
dc.description.abstractMulti-electrode arrays are non-invasive devices for neural stimulation in vivo and in vitro. Improving the efficiency of these devices is desired for stimulating neurons over extended periods of time. In this work, changing the geometry of the electrode used in the array is investigated. This approach will improve efficiency without requiring fundamental changes in the fabrication process, allowing for ease of implementation. A model is presented to study features that provide optimum stimulation threshold from different sizes and shapes of electrodes. Specially, a single neuron-electrode interface was modelled and cell depolarization generated by stimulating the cell by different electrode shapes were compared. The geometries investigated were star, spiral, serpentine, and circular electrode shapes. Based on the simulations, the electrode geometries were designed and then fabricated into a planar microelectrode array test device. Proof of principle in vitro experimentation was then conducted, with the results being compared to the simulations.en_US
dc.identifier.citationGhazavi Khorasgani, A. (2013). Microelectrodes for Neural Stimulation: Effects of Geometry (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26905en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/26905
dc.identifier.urihttp://hdl.handle.net/11023/1136
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectEngineering--Biomedical
dc.subjectEngineering--Electronics and Electrical
dc.subject.classificationFinite element modelingen_US
dc.subject.classificationNeuron stimulationen_US
dc.subject.classificationMicroelectrode arrayen_US
dc.titleMicroelectrodes for Neural Stimulation: Effects of Geometry
dc.typemaster thesis
thesis.degree.disciplineElectrical and Computer Engineering
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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