Trafficking and regulation of neuronal voltage-gated calcium channels

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dc.contributor.authorJarvis, Scott E.
dc.contributor.authorZamponi, Gerald W.
dc.date.accessioned2018-06-06T20:28:37Z
dc.date.available2018-06-06T20:28:37Z
dc.date.issued2007-07-12
dc.description.abstractThe importance of voltage-gated calcium channels is underscored by the multitude of intracellular processes that depend on calcium, notably gene regulation and neurotransmission. Given their pivotal roles in calcium (and hence, cellular) homeostasis, voltage-gated calcium channels have been the subject of intense research, much of which has focused on channel regulation. While ongoing research continues to delineate the myriad of interactions that govern calcium channel regulation, an increasing amount of work has focused on the trafficking of voltage-gated calcium channels. This includes the mechanisms by which calcium channels are targeted to the plasma membrane, and, more specifically, to their appropriate loci within a given cell. In addition, we are beginning to gain some insights into the mechanisms by which calcium channels can be removed from the plasma membrane for recycling and/or degradation. Here we highlight recent advances in our understanding of these fundamentally important mechanisms.en_US
dc.identifier.citationJarvis, S. E., & Zamponi, G. W. (2007, August). Trafficking and regulation of neuronal voltage-gated calcium channels. Current Opinion in Cell Biology. https://doi.org/10.1016/j.ceb.2007.04.020en_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.ceb.2007.04.020en_US
dc.identifier.issn0955-0674
dc.identifier.urihttp://hdl.handle.net/1880/106729
dc.identifier.urihttps://doi.org/10.11575/PRISM/43820
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.publisher.departmentPhysiology & Pharmacologyen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.publisher.policyhttps://www.elsevier.com/about/our-business/policies/sharingen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.titleTrafficking and regulation of neuronal voltage-gated calcium channelsen_US
dc.typejournal articleen_US
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