Assessment of T2 Magnetic Resonance Relaxation as an Imaging Biomarker of Normal Brain Aging over the Adult Lifespan

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dc.contributor.advisorFrayne, Richard
dc.contributor.authorWang, Xing
dc.contributor.committeememberLebel, Catherine A.
dc.contributor.committeememberMcCreary, Cheryl R.
dc.date2021-06
dc.date.accessioned2021-01-22T19:07:03Z
dc.date.available2021-01-22T19:07:03Z
dc.date.issued2021-01-11
dc.description.abstractQuantitative T2 relaxation time (qT2) was proposed for assessing brain tissue changes. In this study, qT2 was evaluated to examine normal brain aging across the adult lifespan. I explored the specific hypotheses that 1) short- (weeks) and long-term (years) qT2 repeatability were equivalent, and 2) qT2 increased with age-related increases in tissue water content and demyelination but decreased with increased iron accumulation. The repeatability assessment found qT2 estimation robust over >4 years. Long-term was similar to, but worse than short-term repeatability. A quadratic regression model was determined to be the best fitting analytical model. Linear mixed effects models were used to evaluate qT2 changes with age in twelve regions and qT2 change rates from six regions compared against a reference region. The results supported the hypothesis that qT2 increases with age; however, could not demonstrate that these T2 changes result from changes in tissue water content, demyelination or iron accumulation.en_US
dc.identifier.citationWang, X. (2021). Assessment of T2 Magnetic Resonance Relaxation as an Imaging Biomarker of Normal Brain Aging over the Adult Lifespan (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/38565
dc.identifier.urihttp://hdl.handle.net/1880/112992
dc.language.isoengen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.subjectbrainen_US
dc.subjectagingen_US
dc.subjectMRIen_US
dc.subjectT2 relaxation timeen_US
dc.subjectage-related tissue property changesen_US
dc.subjectrepeatabilityen_US
dc.subjectregressionen_US
dc.subjectlinear mixed effects (LME) modelen_US
dc.subject.classificationEngineering--Biomedicalen_US
dc.titleAssessment of T2 Magnetic Resonance Relaxation as an Imaging Biomarker of Normal Brain Aging over the Adult Lifespanen_US
dc.typemaster thesisen_US
thesis.degree.disciplineMedicine – Medical Sciencesen_US
thesis.degree.grantorUniversity of Calgaryen_US
thesis.degree.nameMaster of Science (MSc)en_US
ucalgary.item.requestcopytrueen_US
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