Promotion of Peripheral Nerve Regeneration by Uniform Electric Field Application

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atmire.migration.oldid4656
dc.contributor.advisorDalton, Colin
dc.contributor.authorPurdy, Michael
dc.contributor.committeememberDalton, Colin
dc.contributor.committeememberTurner, Raymond W
dc.contributor.committeememberNygren, Anders
dc.contributor.committeememberSyed, Naweed
dc.contributor.committeememberFear, Elise
dc.date.accessioned2016-07-20T15:20:38Z
dc.date.available2016-07-20T15:20:38Z
dc.date.issued2016
dc.date.submitted2016en
dc.description.abstractPeripheral nerve injury is a prevalent condition, afflicting millions of patients around the world and costing the healthcare system billions of dollars. It can lead to sensory loss and debilitating pain, and has a wide range of causes including trauma, infectious diseases, and diabetes. Although peripheral nerves have some inherent ability to regenerate, the recovery process is slow and complex, and regenerative outcomes are limited. However, electrical stimulation has been shown to accelerate recovery. In this work, uniform electric fields are explored in their capacity to encourage neurite outgrowth. A novel microelectrode array is designed to generate uniform fields for application to neurons in vitro, using snail and rat models. In parallel, an implantable nerve cuff was created to apply similar fields in vivo, in injured rat sciatic nerve models. Uniform electric field application was shown to increase overall neuritic outgrowth in snail neurons in vitro.en_US
dc.identifier.citationPurdy, M. (2016). Promotion of Peripheral Nerve Regeneration by Uniform Electric Field Application (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27458en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/27458
dc.identifier.urihttp://hdl.handle.net/11023/3144
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectNeuroscience
dc.subjectEngineering--Biomedical
dc.subject.classificationNerve Regenerationen_US
dc.subject.classificationElectrical Stimulationen_US
dc.subject.classificationperipheral nerveen_US
dc.subject.classificationMicroelectrode arrayen_US
dc.subject.classificationnerve conduiten_US
dc.titlePromotion of Peripheral Nerve Regeneration by Uniform Electric Field Application
dc.typemaster thesis
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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