Metabolomics comparison between Delta and Omicron-infected individuals

dc.contributor.advisorWinston, Brent
dc.contributor.advisorLee, Chel
dc.contributor.authorPimentel Guerrero, Eric Iván
dc.contributor.committeememberHabibi, Hamid
dc.contributor.committeememberMcDonald, Braedon
dc.date2025-02
dc.date.accessioned2025-01-07T20:27:15Z
dc.date.available2025-01-07T20:27:15Z
dc.date.issued2025-01-06
dc.description.abstractAt the end of 2019, SARS-CoV-2, the novel coronavirus emerged causing a widespread increase in airway and lung infections that was driven by different viral variants. Only the variants with significant differences in transmissibility, disease severity, reduction in neutralization by antibodies, and reduction in treatment effectiveness were designated as variants of concern (VOC). Among these variants, the Delta and Omicron forms have demonstrated marked differences in transmissibility and disease severity. This study aims to identify the plasma metabolomics differences that characterize Delta-infected compared to Omicron-infected patients, analyze the severity within these SARS-CoV-2 variant infections, and investigate how vaccination status and corticosteroid treatment impacted the plasma metabolomic profiles of these patients infected with these variants. Our hypothesis is that the metabolomic profiles will reveal significant metabolomic differences between the two variants, reflecting their varied clinical outcomes. Furthermore, we hypothesize that the treatments used during each variant’s wave of infection may be reflected in the plasma metabolome of infected individuals. This study demonstrates that not only are there differences in plasma metabolites that distinguish Delta and Omicron-infected individuals, but also that metabolites do differentiate between various degrees of severity.
dc.identifier.citationPimentel Guerrero, E. I. (YYYY). Metabolomics comparison between delta and omicron-infected individuals (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.
dc.identifier.urihttps://hdl.handle.net/1880/120373
dc.language.isoen
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgary
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectSARS-CoV-2
dc.subjectCOVID-19
dc.subjectDelta
dc.subjectOmicron
dc.subjectMetabolomics
dc.subject.classificationBiochemistry
dc.subject.classificationBiophysics--Medical
dc.subject.classificationVirology
dc.titleMetabolomics comparison between Delta and Omicron-infected individuals
dc.typemaster thesis
thesis.degree.disciplineMedicine – Medical Sciences
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.thesis.accesssetbystudentI require a thesis withhold – I need to delay the release of my thesis due to a patent application, and other reasons outlined in the link above. I have/will need to submit a thesis withhold application.
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