Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese: Cross-Sectional Data from the J-MICC Study

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dc.contributor.authorHishida, Asahi
dc.contributor.authorWakai, Kenji
dc.contributor.authorNaito, Mariko
dc.contributor.authorTamura, Takashi
dc.contributor.authorKawai, Sayo
dc.contributor.authorHamajima, Nobuyuki
dc.contributor.authorOze, Isao
dc.contributor.authorImaizumi, Takeshi
dc.contributor.authorTurin, Tanvir Chowdhury
dc.contributor.authorSuzuki, Sadao
dc.contributor.authorKheradmand, Motahare
dc.contributor.authorMikami, Haruo
dc.contributor.authorOhnaka, Keizo
dc.contributor.authorWatanabe, Yoshiyuki
dc.contributor.authorArisawa, Kokichi
dc.contributor.authorKubo, Michiaki
dc.contributor.authorTanaka, Hideo
dc.date.accessioned2018-09-27T11:43:44Z
dc.date.available2018-09-27T11:43:44Z
dc.date.issued2013-10-27
dc.date.updated2018-09-27T11:43:44Z
dc.description.abstractChronic kidney disease (CKD) is well known as a strong risk factor for both end stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the PPAR genes (PPARD, PPARG, and PPARGC1A) with the risk of CKD in Japanese, we examined this association among the Japanese subjects using the cross-sectional data of J-MICC (Japan Multi-Institutional Collaborative Cohort) Study. The subjects for this analysis were 3,285 men and women, aged 35–69 years, selected from J-MICC Study participants; genotyping was conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3–5 (defined as eGFR ud_less_than 60 ml/min/1.73 m2). Participants with CKD accounted for 17.3% of the study population. When those with PPARD T-842C T/T were defined as reference, those with PPARD T-842C T/C and C/C demonstrated the OR for CKD of 1.26 (95%CI 1.04–1.53) and 1.31 (95%CI 0.83–2.06), respectively. There were no significant associations between the polymorphisms in other PPAR genes and the risk of CKD. The present study found a significantly increased risk of CKD in those with the C allele of PPARD T-842C, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future.
dc.description.versionPeer Reviewed
dc.identifier.citationAsahi Hishida, Kenji Wakai, Mariko Naito, et al., “Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese: Cross-Sectional Data from the J-MICC Study,” PPAR Research, vol. 2013, Article ID 980471, 8 pages, 2013. doi:10.1155/2013/980471
dc.identifier.doihttps://doi.org/10.1155/2013/980471
dc.identifier.urihttp://hdl.handle.net/1880/108287
dc.identifier.urihttps://doi.org/10.11575/PRISM/45521
dc.language.rfc3066en
dc.rights.holderCopyright © 2013 Asahi Hishida et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titlePolymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese: Cross-Sectional Data from the J-MICC Study
dc.typeJournal Article
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