Urinary bisphenol A is associated with dysregulation of HPA-axis function in pregnant women: Findings from the APrON cohort study.

Simple item page
dc.contributor.authorGiesbrecht, Gerald
dc.contributor.authorLiu, Jiaying
dc.contributor.authorEjaredar, Maede
dc.contributor.authorDewey, Deborah
dc.contributor.authorLetourneau, Nicole
dc.contributor.authorCampbell, Tavis
dc.contributor.authorMartin, Jonathan
dc.date.accessioned2016-12-01T00:09:58Z
dc.date.available2016-12-01T00:09:58Z
dc.date.issued2016-11
dc.descriptionAuthor's accepted manuscript deposited according to Elsevier sharing policies: https://www.elsevier.com/about/company-information/policies/policy-faq (November 30th, 2016)en_US
dc.description.abstractBackground: Bisphenol A (BPA) is associated with dysregulation of hypothalamic-pituitary-adrenal (HPA) axis activity in rodents, but evidence in humans is lacking.Objective: To determine whether BPA exposure during pregnancy is associated with dysregulation of the HPA-axis, we examined the association between urinary BPA concentrations and diurnal salivary cortisol in pregnant women. Secondary analyses investigated whether the association between BPA and cortisol was dependent on fetal sex. Methods: Diurnal salivary cortisol and urinary BPA were collected during pregnancy from 174 women in a longitudinal cohort study, the Alberta Pregnancy Outcomes and Nutrition (APrON) study. Associations between BPA and daytime cortisol and the cortisol awakening response (CAR) were estimated using mixed models after adjusting for covariates. Results: Higher concentrations of total BPA uncorrected for urinary creatinine were associated with dysregulation of the daytime cortisol pattern, including reduced cortisol at waking, β=−.055, 95% CI (−.100, −.010) and a flatter daytime pattern, β=.014, 95% CI (.006, .022) and β=−.0007 95% CI (−.001, −.0002) for the linear and quadratic slopes, respectively. Effect sizes in creatinine corrected BPA models were slightly smaller. None of the interactions between fetal sex and BPA were significant (all 95% CI's include zero). Conclusions: These findings provide the first human evidence suggesting that BPA exposure is associated with dysregulation of HPA-axis function during pregnancy.en_US
dc.description.refereedYesen_US
dc.identifier.citationGiesbrecht, G.F., Liu, J., Ejaredar, M., Dewey, D., Letourneau, N., Campbell, T., Martin, J., & the APrON Study Team. (2016). Urinary bisphenol A is associated with dysregulation of HPA axis function in pregnant women: Findings from the APrON cohort study. Environmental Research, 151 (November), 689-697.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33679
dc.identifier.urihttp://hdl.handle.net/1880/51758
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.publisher.corporateUniversity of Calgary
dc.publisher.departmentPaediatricsen_US
dc.publisher.facultyMedicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.publisher.urlhttps://www.elsevier.com/en_US
dc.rightsAttribution Non-Commercial No Derivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectcortisolen_US
dc.subjectpregnancyen_US
dc.subjectbisphenol-Aen_US
dc.subjectHPA-axis functionen_US
dc.subjectcortisol awakening responseen_US
dc.titleUrinary bisphenol A is associated with dysregulation of HPA-axis function in pregnant women: Findings from the APrON cohort study.en_US
dc.typejournal article
thesis.degree.disciplinePaediatrics
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Maternal BPA and HPA axis R1 FINAL clean version.pdf
Size:
999.73 KB
Format:
Adobe Portable Document Format
Description:
Main article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.95 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Cumming School of Medicine Research & Publications