Assessment of the Rat Tapeworm Hymenolepis diminuta and its Antigens in the Treatment of DNBS Colitis

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atmire.migration.oldid3873
dc.contributor.advisorMcKay, Derek
dc.contributor.authorCampbell, Alec
dc.contributor.committeememberRioux, Kevin
dc.contributor.committeememberBuret, Andre
dc.contributor.committeememberMcCafferty, Donna-Marie
dc.contributor.committeememberChadee, Khrisandreth
dc.date.accessioned2016-08-31T15:44:47Z
dc.date.available2016-08-31T15:44:47Z
dc.date.issued2015
dc.date.submitted2015en
dc.description.abstractThe concept of helminth therapy for autoinflammatory disorders is well-established. We utilized the H. diminuta-mouse model system to explore novel therapeutic options. We hypothesized that an optimal treatment regimen for H. diminuta existed which would be ideal for further study. Mice were infected with H. diminuta, or injected with one of two H. diminuta protein extracts, and the impact of this on dinitrobenzene sulphonic acid (DNBS)-induced colitis assessed. We found infection with a single H. diminuta significantly protected mice from DNBS. A single intraperitoneal injection of H. diminuta soluble products was also protective. Selective degradation of H. diminuta soluble products revealed a glycosylated, heat-stable immunomodulator. Finally, treatment with H. diminuta excretory-secretory products was effective at blocking DNBS. We conclude that infection with H. diminuta could be developed therapeutically for IBD and that further studies investigating the mechanism of H. diminuta’s immunomodulation should focus on the study of its excretory-secretory products.en_US
dc.identifier.citationCampbell, A. (2015). Assessment of the Rat Tapeworm Hymenolepis diminuta and its Antigens in the Treatment of DNBS Colitis (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25031en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/25031
dc.identifier.urihttp://hdl.handle.net/11023/3242
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectAnimal Physiology
dc.subjectParasitology
dc.subjectImmunology
dc.subjectPharmacology
dc.titleAssessment of the Rat Tapeworm Hymenolepis diminuta and its Antigens in the Treatment of DNBS Colitis
dc.typemaster thesis
thesis.degree.disciplineGastrointestinal Sciences
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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