Anti-Inflammatory and Cytoprotective Actions of Hydrogen Sulfide: Translation to Therapeutics

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dc.contributor.authorWallace, John L.
dc.contributor.authorBlackler, Rory W.
dc.contributor.authorChan, Melissa V.
dc.contributor.authorDa Silva, Gabriela J.
dc.contributor.authorElsheikh, Wagdi
dc.contributor.authorFlannigan, Kyle L.
dc.contributor.authorGamaniek, Iulia
dc.contributor.authorManko, Anna
dc.contributor.authorWang, Lu
dc.contributor.authorMotta, Jean-Paul
dc.contributor.authorBuret, Andre G.
dc.date.accessioned2016-01-30T22:24:39Z
dc.date.available2016-01-30T22:24:39Z
dc.date.issued2015-04-15
dc.description.abstractSignificance: There is a rapidly expanding body of evidence for important roles of hydrogen sulfide in protecting against tissue injury, reducing inflammation, and promoting repair. There is also growing evidence that H2S can be successfully exploited in drug development. Recent Advances: H2S synthesis and degradation are regulated in circumstances of inflammation and injury so as to promote repair and re-establish homeostasis. Novel H2S-releasing drugs exhibit enhanced anti-inflammatory and pro-restorative effects, while having reduced adverse effects in many tissues. Critical Issues: H2S is a pleiotropic mediator, having effects on many elements in the inflammatory cascade and promoting the resolution of inflammation and injury. It also contributes significantly to mucosal defence in the gastrointestinal tract, and in host defence against infection. There is strong evidence that novel, H2S-based therapeutics are safe and effective in animal models, and several are progressing through human trials. Future Directions: A better understanding of the physiological and pathophysiological roles of H2S continues to be restrained by the lack of simple, reliable methods for measurement of H2S synthesis, and the paucity of highly selective inhibitors of enzymes that participate in endogenous H2S synthesis. On the other hand, H2S donors show promise as therapeutics for several important indications. Antioxid. Redox Signal. 22, 398–410.en_US
dc.description.refereedYesen_US
dc.identifier.doi10.1089/ars.2014.5901
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33871
dc.identifier.urihttp://hdl.handle.net/1880/51072
dc.language.isoenen_US
dc.publisherAntioxidants & Redox Signalingen_US
dc.publisher.corporateUniversity of Calgary
dc.publisher.departmentPhysiology & Pharmacologyen_US
dc.publisher.facultyMedicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.publisher.urlhttp://online.liebertpub.com/doi/abs/10.1089/ars.2014.5901en_US
dc.subjectAnti-Inflammatory Agentsen_US
dc.subjectHydrogen Sulfideen_US
dc.subjectInflammationen_US
dc.subjectProtective Agentsen_US
dc.subjectWounds and Injuriesen_US
dc.titleAnti-Inflammatory and Cytoprotective Actions of Hydrogen Sulfide: Translation to Therapeuticsen_US
dc.typejournal article
thesis.degree.disciplinePhysiology
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