Using magnetic resonance imaging in animal models to guide drug development in multiple sclerosis

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dc.contributor.authorNathoo, Nabeela
dc.contributor.authorYong, V Wee
dc.contributor.authorDunn, Jeffrey F.
dc.contributor.authorBeketskaia, Maria
dc.date.accessioned2017-03-30T22:29:29Z
dc.date.available2017-03-30T22:29:29Z
dc.date.issued2013-11-21
dc.description.abstractMajor advances are taking place in the development of therapeutics for multiple sclerosis (MS), with a move past traditional immunomodulatory/immunosuppressive therapies toward medications aimed at promoting remyelination or neuroprotection. With an increase in diversity of MS therapies comes the need to assess the effectiveness of such therapies. Magnetic resonance imaging (MRI) is one of the main tools used to evaluate the effectiveness of MS therapeutics in clinical trials. As all new therapeutics for MS are tested in animal models first, it is logical that MRI be incorporated into preclinical studies assessing therapeutics. Here, we review key papers showing how MR imaging has been combined with a range of animal models to evaluate potential therapeutics for MS. We also advise on how to maximize the potential for incorporating MRI into preclinical studies evaluating possible therapeutics for MS, which should improve the likelihood of discovering new medications for the condition.en_US
dc.description.grantingagencyCanadian Institutes of Health Research; the Natural Sciences and Engineering Research Council of Canada, Alberta Innovates – Health Solutions; the Multiple Sclerosis Society of Canada; the Alberta endMS Regional Research Training Centre of the endMS Research and Training Network.en_US
dc.description.refereedYesen_US
dc.identifier.doi10.1177/1352458513512709
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33548
dc.identifier.issn1352-4585
dc.identifier.urihttp://hdl.handle.net/1880/51893
dc.language.isoenen_US
dc.publisher.corporateUniversity of Calgary
dc.publisher.departmentRadiologyen_US
dc.publisher.facultyMedicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.publisher.urlSAGE Publicationsen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectexperimental autoimmune encephalomyelitisen_US
dc.subjectTheiler’s murine encephalomyelitis virusen_US
dc.subjectcuprizoneen_US
dc.subjectlysolecithinen_US
dc.subjectdisease-modifying therapiesen_US
dc.titleUsing magnetic resonance imaging in animal models to guide drug development in multiple sclerosisen_US
dc.typejournal article
thesis.degree.disciplineRadiology / Physiology / Clinical Neurosciences
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