Extraintestinal Helminth Infection Limits Pathology and Proinflammatory Cytokine Expression during DSS-Induced Ulcerative Colitis: A Role for Alternatively Activated Macrophages and Prostaglandins

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dc.contributor.authorLedesma-Soto, Yadira
dc.contributor.authorCallejas, Blanca E.
dc.contributor.authorTerrazas, César A.
dc.contributor.authorReyes, Jose L.
dc.contributor.authorEspinoza-Jiménez, Arlett
dc.contributor.authorGonzález, Marisol I.
dc.contributor.authorLeón-Cabrera, Sonia
dc.contributor.authorMorales, Rosario
dc.contributor.authorOlguín, Jonadab E.
dc.contributor.authorSaavedra, Rafael
dc.contributor.authorOghumu, Steve
dc.contributor.authorSatoskar, Abhay R.
dc.contributor.authorTerrazas, Luis I.
dc.date.accessioned2018-09-27T11:27:09Z
dc.date.available2018-09-27T11:27:09Z
dc.date.issued2015-05-18
dc.date.updated2018-09-27T11:27:08Z
dc.description.abstractChronic inflammation of the intestinal mucosa is characteristic of inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease. Helminth parasites have developed immunomodulatory strategies that may impact the outcome of several inflammatory diseases. Therefore, we investigated whether Taenia crassiceps infection is able to decrease the inflammatory effects of dextran sulfate sodium- (DSS-) induced ulcerative colitis in BALB/c and C57BL/6 mice. Preinfection significantly reduced the manifestations of DSS-induced colitis, as weight loss and shortened colon length, and decreased the disease activity index independently of the genetic background of the mice. Taenia infection decreased systemic levels of proinflammatory cytokines while increasing levels of IL-4 and IL-10, and the inflammatory infiltrate into the colon was also markedly reduced. RT-PCR assays from colon showed that T. crassiceps-infected mice displayed increased expression of Arginase-1 but decreased expression of iNOS compared to DSS-treated uninfected mice. The percentages of T regulatory cells were not increased. The adoptive transfer of alternatively activated macrophages (AAMs) from infected mice into mice with DSS-induced colitis reduced the severity of colon inflammation. Administration of indomethacin abrogated the anticolitic effect of Taenia. Thus, T. crassiceps infection limits the pathology of ulcerative colitis by suppressing inflammatory responses mechanistically associated with AAMs and prostaglandins.
dc.description.versionPeer Reviewed
dc.identifier.citationYadira Ledesma-Soto, Blanca E. Callejas, César A. Terrazas, et al., “Extraintestinal Helminth Infection Limits Pathology and Proinflammatory Cytokine Expression during DSS-Induced Ulcerative Colitis: A Role for Alternatively Activated Macrophages and Prostaglandins,” BioMed Research International, vol. 2015, Article ID 563425, 17 pages, 2015. doi:10.1155/2015/563425
dc.identifier.doihttps://doi.org/10.1155/2015/563425
dc.identifier.urihttp://hdl.handle.net/1880/108153
dc.identifier.urihttps://doi.org/10.11575/PRISM/45626
dc.language.rfc3066en
dc.rights.holderCopyright © 2015 Yadira Ledesma-Soto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleExtraintestinal Helminth Infection Limits Pathology and Proinflammatory Cytokine Expression during DSS-Induced Ulcerative Colitis: A Role for Alternatively Activated Macrophages and Prostaglandins
dc.typeJournal Article
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