CSM murray award lecture - functional studies of the Lyme disease spirochete - from molecules to mice

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dc.contributor.authorChaconas, George
dc.date.accessioned2021-04-23T19:16:39Z
dc.date.available2021-04-23T19:16:39Z
dc.date.issued2012-02-17
dc.description.abstractLyme borreliosis, also known as Lyme disease, is now the most common vector transmitted disease in the northern hemisphere. It is caused by the spirochete Borrelia burgdorferi and related species. In addition to their clinical importance, these organisms are fascinating to study because of the wide variety of unusual features they possess. Ongoing work in the laboratory in several areas will be described. (1) The segmented genomes contain up to two dozen genetic elements, the majority of which are linear with covalently closed hairpin ends. These linear DNAs also display a very high degree of ongoing genetic rearrangement. Mechanisms for these processes will be described. (2) Persistent infection by Borrelia species requires antigenic variation through a complex DNA rearrangement process at the vlsE locus on the linear plasmid lp28-1. Novel features of this recombination process will be presented. (3) Evidence for a new global regulatory pathway of B. burgdorferi gene expression that is required for pathogenicity will be described. The DEAH box RNA helicase HrpA is involved in this pathway, which may be relevant in other bacteria. (4) The mechanism of B. burgdorferi to effectively disseminate throughout its host is being studied in real time by high resolution intravital imaging in live mice. Recent work will be presented.en_US
dc.description.grantingagencyCanadian Institutes of Health Research (CIHR)en_US
dc.identifier.citationChaconas, G. CSM Murray Award Lecture — Functional studies of the Lyme disease spirochete — from molecules to mice. Canadian Journal of Microbiology. 58(3): 236-248. https://doi.org/10.1139/w11-143en_US
dc.identifier.doihttp://dx.doi.org/10.1139/w11-143en_US
dc.identifier.grantnumberMOP-53086en_US
dc.identifier.urihttp://hdl.handle.net/1880/113310
dc.identifier.urihttps://doi.org/10.11575/PRISM/43834
dc.language.isoengen_US
dc.publisherCanadian Science Publishingen_US
dc.publisher.departmentBiochemistry & Molecular Biologyen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.hasversionacceptedVersionen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.publisher.policyhttps://cdnsciencepub.com/authors-and-reviewers/author-rightsen_US
dc.titleCSM murray award lecture - functional studies of the Lyme disease spirochete - from molecules to miceen_US
dc.typelectureen_US
ucalgary.item.requestcopyfalseen_US
ucalgary.scholar.levelFacultyen_US
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