Membrane-Associated Thyroid Hormone Receptors Mediate Developmental Angiogenesis in Zebrafish (Danio rerio)

Simple item page
atmire.migration.oldid2828
dc.contributor.advisorHabibi, Hamid
dc.contributor.authorKonschuh, Shaelen Alanna
dc.date.accessioned2015-01-08T16:16:07Z
dc.date.available2015-02-23T08:00:37Z
dc.date.issued2015-01-08
dc.date.submitted2014en
dc.description.abstractThyroid hormone (TH) is an important regulator of growth, differentiation, and metabolism. The function of nuclear thyroid receptors, which are ligand-activated transcription factors that regulate gene expression, has been well-studied. However, TH also induces signaling events that are mediated by a recently discovered membrane receptor. Angiogenesis has been identified as a downstream physiological function influenced by TH membrane signaling. The primary objective of my thesis was to investigate the role of TH in the developing vertebrate vasculature during embryogenesis. My study provides important novel information showing that TH is involved in angiogenesis during embryonic development in the zebrafish and regulates vascular sprouting, morphology, and patterning. I have also shown that the control of angiogenesis by TH is only partially influenced by changes in the expression level of angiogenic genes. The limited transcriptional sensitivity that I observed indicates it is likely that other factors predominantly underlie the vascular response to TH.en_US
dc.identifier.citationKonschuh, S. A. (2015). Membrane-Associated Thyroid Hormone Receptors Mediate Developmental Angiogenesis in Zebrafish (Danio rerio) (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26875en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/26875
dc.identifier.urihttp://hdl.handle.net/11023/1992
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectAnimal Physiology
dc.subjectBiology--Molecular
dc.subjectPhysiology
dc.subject.classificationthyroid hormoneen_US
dc.subject.classificationangiogenesisen_US
dc.subject.classificationDevelopmenten_US
dc.subject.classificationPhysiologyen_US
dc.subject.classificationendocrinologyen_US
dc.titleMembrane-Associated Thyroid Hormone Receptors Mediate Developmental Angiogenesis in Zebrafish (Danio rerio)
dc.typemaster thesis
thesis.degree.disciplineBiological Sciences
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ucalgary_2014_konschuh_shaelen.pdf
Size:
1.84 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.65 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Open Theses and Dissertations