Neurophysiological and diffusion tensor imaging correlates of mild traumatic brain injury in children

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dc.contributor.advisorKirton, Adam
dc.contributor.advisorBarlow, Karen
dc.contributor.authorKing, Regan
dc.contributor.committeememberLebel, Catherine A.
dc.contributor.committeememberEsser, Michael J.
dc.contributor.committeememberFederico, Paolo
dc.date2018-11
dc.date.accessioned2018-07-31T14:31:13Z
dc.date.available2018-07-31T14:31:13Z
dc.date.issued2018-07-24
dc.description.abstractChildren typically recover quickly following a mild traumatic brain injury (mTBI), however up to 15% of children continue to experience symptoms past three months post injury. Currently, underlying mechanisms of persistent post-concussive symptoms (PPCS) in children are unknown. The present thesis uses transcranial magnetic stimulation (TMS) and diffusion tensor imaging (DTI) to characterize the structural and functional characteristics of PPCS in 98 children (aged 8-18) with mTBI, over time. The Post-concussive Symptom Inventory (PCSI) was used to classify post-concussive symptoms in participants as symptomatic or asymptomatic. Twenty-six healthy controls were included for comparison. Neurophysiological data assessing cortical inhibition and facilitation were evaluated alongside symptom status. Associations between symptom status and DTI measures of water diffusion and anisotropy were also assessed in the corticospinal tract (CST), motor fibers of the corpus callosum (CC), and uncinate fasciculus (UF). Differences in neurophysiology were noted between healthy controls and children with mTBI in both inhibitory and excitatory TMS paradigms, further differentiating by symptom status. Differences in inhibitory paradigms were also noted over time. Fractional anisotropy (FA) differed as well in the UF, but not in the CST or CC, of symptomatic children compared to controls. No differences in diffusion metrics were observed over time. In summary, these findings suggest an indirect association of neurophysiology and white matter structure in mTBI recovery. Further exploration of neurophysiological and imaging correlates of PPCS are required to improve recovery and treatment outcomes of mTBI.en_US
dc.identifier.citationKibng, R. (2018). Neurophysiological and diffusion tensor imaging correlates of mild traumatic brain injury in children (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/32711en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/32711
dc.identifier.urihttp://hdl.handle.net/1880/107530
dc.language.isoeng
dc.publisher.facultyCumming School of Medicine
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subject.classificationNeuroscienceen_US
dc.titleNeurophysiological and diffusion tensor imaging correlates of mild traumatic brain injury in children
dc.typemaster thesis
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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