Impact of Physical Activity on Oxidative Stress Markers in Patients with Metastatic Breast Cancer

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dc.contributor.authorDelrieu, Lidia
dc.contributor.authorTouillaud, Marina
dc.contributor.authorPérol, Olivia
dc.contributor.authorMorelle, Magali
dc.contributor.authorMartin, Agnès
dc.contributor.authorFriedenreich, Christine M.
dc.contributor.authorMury, Pauline
dc.contributor.authorDufresne, Armelle
dc.contributor.authorBachelot, Thomas
dc.contributor.authorHeudel, Pierre-Etienne
dc.contributor.authorFervers, Béatrice
dc.contributor.authorTrédan, Olivier
dc.contributor.authorPialoux, Vincent
dc.date.accessioned2021-07-18T08:00:18Z
dc.date.available2021-07-18T08:00:18Z
dc.date.issued2021-07-16
dc.date.updated2021-07-18T08:00:18Z
dc.description.abstractPurpose. Regular physical activity (PA) can affect oxidative stress, known to be involved in carcinogenesis. The objective of this study was to evaluate the associations between a six-month PA intervention and oxidative stress biomarkers, PA, and clinical outcomes in patients with metastatic breast cancer. Methods. Forty-nine newly diagnosed patients with metastatic breast cancer were recruited for a single-arm, unsupervised, and personalized six-month walking intervention with activity tracker. PA level and PA fitness, plasma concentrations of DNA oxidation (8OhdG), lipid peroxidation (MDA), and protein oxidation (AOPP), plasma activities of superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase, plasma and leucocyte activities of myeloperoxidase (MPO) and NADPH oxidase (NOX), and clinical markers of tumor progression (RECIST criteria) were measured at baseline and after the six-month intervention. Results. GPX activity (+17%) and MDA (+9%) significantly increased between baseline and the end of the intervention. Changes in PA level and fitness were significantly positively correlated with changes in plasma GPX and significantly negatively with changes in NOX in the leucocytes. Plasma MDA was significantly higher (+20%) whereas plasma AOPP was lower (-46%) for patients with tumor progression or that died during the six months as compared to patients without progression. Conclusion. A six-month PA intervention may be potentially beneficial in metastatic breast cancer patients for enhancing antioxidant enzyme activity and decreasing prooxidant enzyme activity. Moreover, AOPP and MDA could also be favorable and unfavorable biomarkers, respectively, since they are associated with disease progression and fitness level in this population. This trial is registered with NCT number: NCT03148886.
dc.description.versionPeer Reviewed
dc.identifier.citationLidia Delrieu, Marina Touillaud, Olivia Pérol, et al., “Impact of Physical Activity on Oxidative Stress Markers in Patients with Metastatic Breast Cancer,” Oxidative Medicine and Cellular Longevity, vol. 2021, Article ID 6694594, 9 pages, 2021. doi:10.1155/2021/6694594
dc.identifier.urihttp://dx.doi.org/10.1155/2021/6694594
dc.identifier.urihttp://hdl.handle.net/1880/113642
dc.identifier.urihttps://dx.doi.org/10.11575/PRISM/39016
dc.language.rfc3066en
dc.rights.holderCopyright © 2021 Lidia Delrieu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleImpact of Physical Activity on Oxidative Stress Markers in Patients with Metastatic Breast Cancer
dc.typeJournal Article
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