Effect of Acute, Subacute, and Repeated Exposure to High Altitude (5050 m) on Psychomotor Vigilance

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dc.contributor.authorPun, Matiram
dc.contributor.authorHartmann, Sara E.
dc.contributor.authorFurian, Michael
dc.contributor.authorDyck, Adrienna M.
dc.contributor.authorMuralt, Lara
dc.contributor.authorLichtblau, Mona
dc.contributor.authorBader, Patrick R.
dc.contributor.authorUlrich, Silvia
dc.contributor.authorBloch, Konrad E.
dc.contributor.authorRawling, Jean M.
dc.contributor.authorPoulin, Marc J.
dc.date.accessioned2018-08-01T15:37:16Z
dc.date.available2018-08-01T15:37:16Z
dc.date.issued2018-01
dc.description.abstractAim: High altitude (HA) hypoxia may affect cognitive performance and sleep quality. Further, vigilance is reduced following sleep deprivation. We investigated the effect on vigilance, actigraphic sleep indices, and their relationships with acute mountain sickness (AMS) during very HA exposure, acclimatization, and re-exposure. Methods: A total of 21 healthy altitude-naive individuals (25 ± 4 years; 13 females) completed 2 cycles of altitude exposure separated by 7 days at low altitude (LA, 520 m). Participants slept at 2900 m and spent the day at HA, (5050 m). We report acute altitude exposure on Day 1 (LA vs. HA1) and after 6 days of acclimatization (HA1 vs. HA6). Vigilance was quantified by reaction speed in the 10-min psychomotor vigilance test reaction speed (PVT-RS). AMS was evaluated using the Environmental Symptoms Questionnaire Cerebral Score (AMS-C score). Nocturnal rest/activity was recorded to estimate sleep duration using actigraphy. Results: In Cycle 1, PVT-RS was slower at HA1 compared to LA (4.1 ± 0.8 vs. 4.5 ± 0.6 s-1, respectively, p = 0.029), but not at HA6 (4.6 ± 0.7; p > 0.05). In Cycle 2, PVT-RS at HA1 (4.6 ± 0.7) and HA6 (4.8 ± 0.6) were not different from LA (4.8 ± 0.6, p > 0.05) and significantly greater than corresponding values in Cycle 1. In both cycles, AMS scores were higher at HA1 than at LA and HA6 (p < 0.05). Estimated sleep durations (TST) at LA, 1st and 5th nights were 431.3 ± 28.7, 418.1 ± 48.6, and 379.7 ± 51.4 min, respectively, in Cycle 1 and they were significantly reduced during acclimatization exposures (LA vs. 1st night, p > 0.05; LA vs. 5th night, p = 0.012; and 1st vs. 5th night, p = 0.054). LA, 1st and 5th nights TST in Cycle 2 were 477.5 ± 96.9, 430.9 ± 34, and 341.4 ± 32.2, respectively, and we observed similar deteriorations in TST as in Cycle 1 (LA vs. 1st night, p > 0.05; LA vs. 5th night, p = 0.001; and 1st vs. 5th night, p < 0.0001). At HA1, subjects who reported higher AMS-C scores exhibited slower PVT-RS (r = -0.56; p < 0.01). Subjects with higher AMS-C scores took longer time to react to the stimuli during acute exposure (r = 0.62, p < 0.01) during HA1 of Cycle 1. Conclusion: Acute exposure to HA reduces the PVT-RS. Altitude acclimatization over 6 days recovers the reaction speed and prevents impairments during subsequent altitude re-exposure after 1 week spent near sea level. However, acclimatization does not lead to improvement in total sleep time during acute and subacute exposures.en_US
dc.description.sponsorshipSponsored by the Open Access Authors Funden_US
dc.identifier.citationPun, M., Hartmann, S. E., Furian, M., Dyck, A. M., Muralt, L., Lichtblau, M., . . . Poulin, M. J. (2018). Effect of acute, subacute, and repeated exposure to high altitude (5050 m) on psychomotor vigilance. Frontiers in Physiology, 9(JUN) doi:10.3389/fphys.2018.00677en_US
dc.identifier.doihttp://dx.doi.org/10.3389/fphys.2018.00677en_US
dc.identifier.issn1664-042X
dc.identifier.urihttp://hdl.handle.net/1880/107571
dc.identifier.urihttps://doi.org/10.11575/PRISM/43838
dc.language.isoenen_US
dc.publisherFrontiers in Physiologyen_US
dc.publisher.departmentPhysiology & Pharmacologyen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.publisher.policyhttps://www.frontiersin.org/about/author-guidelinesen_US
dc.rightsUnless otherwise indicated, this material is protected by copyright and has been made available with authorization from the copyright owner. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.titleEffect of Acute, Subacute, and Repeated Exposure to High Altitude (5050 m) on Psychomotor Vigilanceen_US
dc.typeunknown
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