Innate and Adaptive Cell Populations Driving Inflammation in Dry Eye Disease

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dc.contributor.authorReyes, José L.
dc.contributor.authorVannan, Danielle T.
dc.contributor.authorEksteen, Bertus
dc.contributor.authorAvelar, Imelda Juárez
dc.contributor.authorRodríguez, Tonathiu
dc.contributor.authorGonzález, Marisol Ibet
dc.contributor.authorMendoza, Alicia Vázquez
dc.date.accessioned2018-09-26T07:28:26Z
dc.date.available2018-09-26T07:28:26Z
dc.date.issued2018-08-12
dc.date.updated2018-09-26T07:28:26Z
dc.description.abstractDry eye disease (DED) is the most common ocular disease and affects millions of individuals worldwide. DED encompasses a heterogeneous group of diseases that can be generally divided into two forms including aqueous-deficient and evaporative DED. Evidence suggests that these conditions arise from either failure of lacrimal gland secretion or low tear film quality. In its secondary form, DED is often associated with autoimmune diseases such as Sjögren’s syndrome and rheumatoid arthritis. Current treatment strategies for DED are limited to anti-inflammatory medications that target the immune system as the source of deleterious inflammation and tissue injury. However, there is a lack of understanding of the underlying pathogenesis of DED, and subsequently, there are very few effective treatment strategies. The gap in our knowledge of the etiology of primary DED is in part because the majority of research in DED focused on secondary autoimmune causes. This review focuses on what is currently understood about the contribution of innate and adaptive immune cell populations in the pathogenesis of DED and highlights the need to continue investigating the central role of immunity driving DED.
dc.description.versionPeer Reviewed
dc.identifier.citationJosé L. Reyes, Danielle T. Vannan, Bertus Eksteen, et al., “Innate and Adaptive Cell Populations Driving Inflammation in Dry Eye Disease,” Mediators of Inflammation, vol. 2018, Article ID 2532314, 12 pages, 2018. doi:10.1155/2018/2532314
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/32983
dc.identifier.urihttp://dx.doi.org/10.1155/2018/2532314
dc.identifier.urihttp://hdl.handle.net/1880/107820
dc.language.rfc3066en
dc.rights.holderCopyright © 2018 José L. Reyes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleInnate and Adaptive Cell Populations Driving Inflammation in Dry Eye Disease
dc.typeJournal Article
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