Cell Surface Receptors Expression Profile Of Human Synovial Mesenchymal Stem Cells In-Situ And In-Vitro From Normal And Osteoarthritic Knee Joints
Abstract
Osteoarthritis is a chronic disease that results in the degeneration of the articular cartilage, eventually affecting the whole joint. Due to the lack of regenerative capacity in the articular cartilage, synovial mesenchymal stem cells, having chondrogenic capacity and derived from the synovium (SMSCs) are an attractive source for articular cartilage regeneration. However, it is important to identify the optimal SMSCs that have tri-lineage potential, which will help the regeneration of the whole joint. Unfortunately, MSC populations are phenotypically heterogeneous, in terms of their cell surface expression. In this project, SMSCs derived from OA joint with the optimal differentiation capacity display a marker profile of CD90+, CD44+, and CD73+. However, the same profile was expressed on clones that didn’t present with multi-potential differentiation capacity. Therefore, additional markers are necessary to accurately purify SMSCs that would may have increased regenerative capacity for use in cell therapies for patients with OA.
Description
Keywords
Human Development, Medicine and Surgery
Citation
Al-Jezani, N. (2016). Cell Surface Receptors Expression Profile Of Human Synovial Mesenchymal Stem Cells In-Situ And In-Vitro From Normal And Osteoarthritic Knee Joints (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25235