Near-infrared measurements of brain oxygenation in stroke

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dc.contributor.authorMoreau, Francois
dc.contributor.authorYang, Runze
dc.contributor.authorNambiar, Vivek
dc.contributor.authorDemchuk, Andrew M.
dc.contributor.authorDunn, Jeff F.
dc.date.accessioned2017-03-13T21:58:34Z
dc.date.available2017-03-13T21:58:34Z
dc.date.issued2016-02-11
dc.description.abstractWe investigated the feasibility of using frequency-domain near-infrared spectroscopy (fdNIRS) to study brain oxygenation in the first few hours of stroke onset. The OxiplexTS® fdNIRS system was used in this study. Using a standard probing protocol based on surface landmarks, we measured brain tHb and StO2 in healthy volunteers, cadavers, and acute stroke patients within 9 h of stroke onset and 3 days later. We obtained measurements from 11 controls, 5 cadavers, and 5 acute stroke patients. StO2 values were significantly lower in cadavers compared to the controls and stroke patients. Each stroke patient had at least one area with reduced StO2 on the stroke side compared to the contralateral side. The evolution of tHb and StO2 at 3 days differed depending on whether a large infarct occurred. This study shows the proof of principle that quantified measurements of brain oxygenation using NIRS could be used in the hectic environment of acute stroke management. It also highlights the current technical limitations and future challenges in the development of this unique bedside monitoring tool for stroke.en_US
dc.description.grantingagencyNational Sciences and Engineering Research Council; Alberta Innovates Health Solutionsen_US
dc.description.refereedYesen_US
dc.identifier.citationFrançois Moreau et al. Near-infrared measurements of brain oxygenation in stroke.Neurophoton. 3(3), 031403 (Feb 11, 2016).en_US
dc.identifier.doi10.1117/1.NPh.3.3.031403
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33521
dc.identifier.issn2329-423X
dc.identifier.urihttp://hdl.handle.net/1880/51852
dc.language.isoenen_US
dc.publisherSociety of Photo-optical Instrumentation Engineersen_US
dc.publisher.corporateUniversity of Calgary
dc.publisher.departmentMedicineen_US
dc.publisher.facultyMedicineen_US
dc.publisher.institutionUniversite de Sherbrookeen_US
dc.subjectstrokeen_US
dc.subjectischemicen_US
dc.subjectbrain imagingen_US
dc.subjectnear-infrareden_US
dc.titleNear-infrared measurements of brain oxygenation in strokeen_US
dc.typejournal article
thesis.degree.disciplineRadiology / Physiology / Clinical Neurosciences
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