Investigating the Functional Role of Aquaporin 3 in Intestinal Epithelial Cells

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atmire.migration.oldid4617
dc.contributor.advisorMacNaughton, Wallace
dc.contributor.authorMorgan, Elizabeth Ellen
dc.contributor.committeememberMcKay, Derek
dc.contributor.committeememberBeck, Paul
dc.contributor.committeemembervon der Weid, Pierre-Yves
dc.date.accessioned2016-07-11T20:15:31Z
dc.date.available2016-07-11T20:15:31Z
dc.date.issued2016
dc.date.submitted2016en
dc.description.abstractWater is the most abundant molecule in human cells and biological systems, and aquaporin (AQP) proteins have an important role in facilitating transepithelial transport of water. Aquaporin 3 (AQP3) is an aquaglyceroporin that is permeable to water and small solutes, and is expressed in intestinal epithelial cells. Inflammatory bowel diseases are associated with barrier dysfunction and altered absorption and secretion. Given that AQPs are involved in these processes, and are decreased in IBD, we sought to better understand the importance of AQP3 in epithelial cells of the gastrointestinal tract. Our studies show that in the absence of AQP3, HT29 adenocarcinoma cells exhibit impaired growth which is due to decreased proliferation caused by an arrest in G2/M phase of the cell cycle, and not increased rates of cell death. These results improve the understanding of the functional role and importance of AQP3 in intestinal epithelial cell homeostasis.en_US
dc.identifier.citationMorgan, E. E. (2016). Investigating the Functional Role of Aquaporin 3 in Intestinal Epithelial Cells (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26641en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/26641
dc.identifier.urihttp://hdl.handle.net/11023/3118
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectBiology--Cell
dc.subjectBiology--Molecular
dc.subject.classificationAquaporinen_US
dc.subject.classificationInflammatory Bowel Diseaseen_US
dc.subject.classificationGastrointestinalen_US
dc.titleInvestigating the Functional Role of Aquaporin 3 in Intestinal Epithelial Cells
dc.typemaster thesis
thesis.degree.disciplineGastrointestinal Sciences
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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