Phospholipase A2 Receptor and α-enolase in the Immunodiagnosis of membranous nephropathy

Simple item page
atmire.migration.oldid2909
dc.contributor.advisorBenediktsson, Hallgrímur
dc.contributor.authorZhang, Ying
dc.date.accessioned2015-02-02T23:59:05Z
dc.date.available2015-06-23T07:00:44Z
dc.date.issued2015-02-02
dc.date.submitted2015en
dc.description.abstractM-type phospholipase A2 receptor (PLA2R) and α-enolase are two recently identified autoantigens in adult idiopathic membranous nephropathy (IMN). To identify their diagnostic value and the potential roles in the pathogenesis of MN, renal biopsies and sera from 23 patients with MN were investigated. In 19 IMN cases, the positivity for glomerular PLA2R and circulating anti-PLA2R antibodies was 47% and 26% respectively, while only 5% glomeruli showed positive α-enolase staining. IgG4 was often codominant with either IgG1 or IgG3 in PLA2R-positive glomeruli which also showed more prevalent and stronger C3 staining as compared with PLA2R-negative glomeruli. A positive correlation between IgG1 with complement C3C expression in glomeruli was observed. Circulating anti-PLA2R autoantibody titers and PLA2R expression in renal biopsies were associated with clinical outcomes (follow up proteinuria). The results indicate that in PLA2R related MN, autoantibody –antigen interaction activates complement C3 directly or indirectly, resulting in podocyte injury and proteinuria.en_US
dc.identifier.citationZhang, Y. (2015). Phospholipase A2 Receptor and α-enolase in the Immunodiagnosis of membranous nephropathy (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27335en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/27335
dc.identifier.urihttp://hdl.handle.net/11023/2060
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectEducation--Health
dc.subject.classificationM-type phospholipase A2 receptoren_US
dc.subject.classificationα-enolaseen_US
dc.subject.classificationidiopathic membranous nephropathyen_US
dc.titlePhospholipase A2 Receptor and α-enolase in the Immunodiagnosis of membranous nephropathy
dc.typemaster thesis
thesis.degree.disciplineMedical Science
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ucalgary_2015_zhang_ying.pdf
Size:
1.23 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.65 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Open Theses and Dissertations