Direct Microbicidal Activity of Cytotoxic T-Lymphocytes

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dc.contributor.authorOykhman, Paul
dc.contributor.authorMody, Christopher H.
dc.date.accessioned2018-09-27T12:01:55Z
dc.date.available2018-09-27T12:01:55Z
dc.date.issued2010-06-23
dc.date.updated2018-09-27T12:01:55Z
dc.description.abstractCytotoxic T-lymphocytes (CTL) are famous for their ability to kill tumor, allogeneic and virus-infected cells. However, an emerging literature has now demonstrated that CTL also possess the ability to directly recognize and kill bacteria, parasites, and fungi. Here, we review past and recent findings demonstrating the direct microbicidal activity of both CD4+ and CD8+ CTL against various microbial pathogens. Further, this review will outline what is known regarding the mechanisms of direct killing and their underlying signalling pathways.
dc.description.versionPeer Reviewed
dc.identifier.citationPaul Oykhman and Christopher H. Mody, “Direct Microbicidal Activity of Cytotoxic T-Lymphocytes,” Journal of Biomedicine and Biotechnology, vol. 2010, Article ID 249482, 9 pages, 2010. doi:10.1155/2010/249482
dc.identifier.doihttps://doi.org/10.1155/2010/249482
dc.identifier.urihttp://hdl.handle.net/1880/108441
dc.identifier.urihttps://doi.org/10.11575/PRISM/45847
dc.language.rfc3066en
dc.rights.holderCopyright © 2010 Paul Oykhman and Christopher H. Mody. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleDirect Microbicidal Activity of Cytotoxic T-Lymphocytes
dc.typeJournal Article
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