Intrapartum glycemic control and neonatal hypoglycemia in pregnancies complicated by diabetes

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dc.contributor.advisorWood, Stephen L.
dc.contributor.authorYamamoto, Jennifer M.
dc.contributor.committeememberDonovan, Lois E.
dc.contributor.committeememberMohammad, Khorshid
dc.date2019-06
dc.date.accessioned2019-04-18T18:29:47Z
dc.date.available2019-04-18T18:29:47Z
dc.date.issued2019-04-17
dc.description.abstractNeonatal hypoglycemia is common following pregnancies complicated by diabetes. Current dogma suggests that tight intrapartum glycemic control decreases the risk of neonatal hypoglycemia by avoiding an acute rise in fetal insulin prior to delivery. This thesis reports on two studies that bring to question the association between intrapartum glycemic control and the risk of neonatal hypoglycemia. The first is a systematic review that highlights the paucity of high-quality evidence confirming an association between intrapartum glycemic control and neonatal hypoglycemia. The second is the largest cohort to date examining this relationship. It found that after adjustment for important neonatal confounders, in-target intrapartum glycemic control was not significantly associated with neonatal hypoglycemia. When taken as whole, these studies question current guidelines recommending tight intrapartum glycemic control and call for a randomized controlled trial of tight versus more relaxed glycemic targets during the labour and delivery period.en_US
dc.identifier.citationYamamoto, J. M. (2019). Intrapartum glycemic control and neonatal hypoglycemia in pregnancies complicated by diabetes (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/36369
dc.identifier.urihttp://hdl.handle.net/1880/110176
dc.language.isoengen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.subjectDiabetesen_US
dc.subjectPregnancyen_US
dc.subjectNeonatal hypoglycemiaen_US
dc.subjectIntravenous insulinen_US
dc.subjectGlycemic controlen_US
dc.subjectLabour and deliveryen_US
dc.subjectIntrapartumen_US
dc.subject.classificationEpidemiologyen_US
dc.subject.classificationMedicine and Surgeryen_US
dc.subject.classificationObstetrics and Gynecologyen_US
dc.titleIntrapartum glycemic control and neonatal hypoglycemia in pregnancies complicated by diabetesen_US
dc.typemaster thesisen_US
thesis.degree.disciplineMedicine – Community Health Sciencesen_US
thesis.degree.grantorUniversity of Calgaryen_US
thesis.degree.nameMaster of Science (MSc)en_US
ucalgary.item.requestcopytrue
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