Advancing Concussion Assessment in Pediatrics (A-CAP): a prospective, concurrent cohort, longitudinal study of mild traumatic brain injury in children: protocol study

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dc.contributor.authorYeates, Keith O.
dc.contributor.authorBeauchamp, Miriam
dc.contributor.authorCraig, William
dc.contributor.authorDoan, Quynh
dc.contributor.authorZemek, Roger
dc.contributor.authorBjornson, Bruce H.
dc.contributor.authorGravel, Jocelyn
dc.contributor.authorMikrogianakis, Angelo
dc.contributor.authorGoodyear, Bradley
dc.contributor.authorAbdeen, Nishard
dc.contributor.authorBeaulieu, Christian
dc.contributor.authorDehaes, Mathieu
dc.contributor.authorDeschenes, Sylvain
dc.contributor.authorHarris, Ashley D.
dc.contributor.authorLebel, Catherine
dc.contributor.authorLamont, Ryan
dc.contributor.authorWilliamson, Tyler
dc.contributor.authorBarlow, Karen M.
dc.contributor.authorBernier, Francois
dc.contributor.authorBrooks, Brian L.
dc.contributor.authorEmery, Carolyn
dc.contributor.authorFreedman, Stephen B.
dc.contributor.authorKowalski, Kristina
dc.contributor.authorMrklas, Kelly
dc.contributor.authorTomfohr-Madsen, Lianne
dc.contributor.authorSchneider, Kathryn J.
dc.date.accessioned2021-01-06T20:50:54Z
dc.date.available2021-01-06T20:50:54Z
dc.date.issued2017-07-01
dc.description.abstractIntroduction Paediatric mild traumatic brain injury (mTBI) is a public health burden. Clinicians urgently need evidence-based guidance to manage mTBI, but gold standards for diagnosing and predicting the outcomes of mTBI are lacking. The objective of the Advancing Concussion Assessment in Pediatrics (A-CAP) study is to assess a broad pool of neurobiological and psychosocial markers to examine associations with postinjury outcomes in a large sample of children with either mTBI or orthopaedic injury (OI), with the goal of improving the diagnosis and prognostication of outcomes of paediatric mTBI. Methods and analysis A-CAP is a prospective, longitudinal cohort study of children aged 8.00-16.99 years with either mTBI or OI, recruited during acute emergency department (ED) visits at five sites from the Pediatric Emergency Research Canada network. Injury information is collected in the ED; follow-up assessments at 10 days and 3 and 6 months postinjury measure a variety of neurobiological and psychosocial markers, covariates/confounders and outcomes. Weekly postconcussive symptom ratings are obtained electronically. Recruitment began in September 2016 and will occur for approximately 24 months. Analyses will test the major hypotheses that neurobiological and psychosocial markers can: (1) differentiate mTBI from OI and (2) predict outcomes of mTBI. Models initially will focus within domains (eg, genes, imaging biomarkers, psychosocial markers), followed by multivariable modelling across domains. The planned sample size (700 mTBI, 300 OI) provides adequate statistical power and allows for internal cross-validation of some analyses. Ethics and dissemination The ethics boards at all participating institutions have approved the study and all participants and their parents will provide informed consent or assent. Dissemination will follow an integrated knowledge translation plan, with study findings presented at scientific conferences and in multiple manuscripts in peer-reviewed journals.
dc.description.grantingagencyCanadian Institutes of Health Research - Foundation Scheme
dc.description.grantingagencyOther
dc.identifier.citationYeates, K. O., Beauchamp, M., Craig, W., Doan, Q., Zemek, R., Bjornson, B., Gravel, J., Mikrogianakis, A., Goodyear, B., Abdeen, N., Beaulieu, C., Dehaes, M., Deschenes, S., Harris, A., Lebel, C., Lamont, R., Williamson, T., Barlow, K. M., Bernier, F., … Schneider, K. J. (2017). Advancing Concussion Assessment in Pediatrics (A-CAP): a prospective, concurrent cohort, longitudinal study of mild traumatic brain injury in children: protocol study. BMJ Open, 7(7), e017012. https://doi.org/10.1136/bmjopen-2017-017012
dc.identifier.doi10.1136/bmjopen-2017-017012
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/38520
dc.identifier.issn2044-6055
dc.identifier.urihttp://hdl.handle.net/1880/112928
dc.language.isoeng
dc.publisherBMJ
dc.publisher.hasversionPublisher's version
dc.publisher.policyhttps://www.bmj.com/company/products-services/rights-and-licensing/author-self-archiving-and-permissions/
dc.rights© Article author(s)
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.titleAdvancing Concussion Assessment in Pediatrics (A-CAP): a prospective, concurrent cohort, longitudinal study of mild traumatic brain injury in children: protocol study
dc.typejournal article
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