Effect of Cafeteria Diet Induced Obesity on Neuroinflammation in the Orbitofrontal Cortex

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atmire.migration.oldid4752
dc.contributor.advisorBorgland, Stephanie
dc.contributor.authorKaur, Manpreet
dc.contributor.committeememberPittman, Quentin J.
dc.contributor.committeememberTrang, Tuan
dc.date.accessioned2016-08-19T17:27:35Z
dc.date.available2016-08-19T17:27:35Z
dc.date.issued2016
dc.date.submitted2016en
dc.description.abstractPalatable food consumption is associated with obesity and induce inflammation in brain. The orbitofrontal cortex is implicated in compulsive behavior. Glial changes lead to synaptic remodeling and altered behavior. However it is not clear if metabolic changes associated with cafeteria diet consumption lead to glial changes in OFC. My study addressed this important question whether intake of cafeteria diet leads to glial changes in OFC. I observed that rats with extended access to cafeteria diet become obese, exhibited inflexible behaviour and increased GFAP and IBA1 expression in the hippocampus and the hypothalamus. Further, there was an increase observed in several proinflammatory cytokines in the hypothalamus. My work has shown that extended intake of cafeteria diet is associated with increased GFAP expression in OFC without any changes in IBA1 expression, proliferation and the levels of proinflammatory cytokines. This is the first study reporting astrocytic activation in OFC associated with compulsive food intake.en_US
dc.identifier.citationKaur, M. (2016). Effect of Cafeteria Diet Induced Obesity on Neuroinflammation in the Orbitofrontal Cortex (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25791en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/25791
dc.identifier.urihttp://hdl.handle.net/11023/3193
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectEducation--Sciences
dc.subjectNeuroscience
dc.subjectNutrition
dc.subjectPsychology--Cognitive
dc.subject.classificationCafeteria dieten_US
dc.subject.classificationOrbitofrontal cortexen_US
dc.subject.classificationHippocampusen_US
dc.subject.classificationHypothalamusen_US
dc.subject.classificationCognitive inflexibiltyen_US
dc.subject.classificationConditioned suppression behaviouren_US
dc.subject.classificationMicrogliaen_US
dc.subject.classificationAstrocytesen_US
dc.subject.classificationNeuroinflammationen_US
dc.subject.classificationCytokinesen_US
dc.titleEffect of Cafeteria Diet Induced Obesity on Neuroinflammation in the Orbitofrontal Cortex
dc.typemaster thesis
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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