The Role of Procalcitonin Measurements in Predicting Clinical Outcomes in Critically Ill/Injured Patients

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dc.contributor.advisorKirkpatrick, Andrew Wallace
dc.contributor.advisorDoig, Christopher James
dc.contributor.authorAl Rawahi, Aziza
dc.contributor.committeememberBall, Chad Geoffrey G.
dc.contributor.committeememberDixon, Elijah G.
dc.date2019-11
dc.date.accessioned2019-07-15T20:54:41Z
dc.date.available2019-07-15T20:54:41Z
dc.date.issued2019-07-12
dc.description.abstractBackground: Major trauma is associated with high incidence of septic complications and multiple organ dysfunction (MOD). We assessed the prognostic value of serum and peritoneal procalcitonin (PCT) levels after trauma. Methods: We searched electronic database and included original studies that assessed prognostic value of PCT after trauma. We performed a retrospective analysis of the Intraperitoneal Vacuum Trial to assess correlation of plasma and peritoneal levels of PCT with clinical outcomes in patients managed with the open abdomen (OA) technique. Results: Among 2,015 citations identified, 19 studies met inclusion criteria. All studies showed a strong correlation between initial PCT levels and Injury Severity Score (ISS). Initial peak PCT levels predicted development of sepsis and MOD after trauma. Conclusion: PCT seems to hold promise as a surrogate biomarker for trauma. Initial peak PCT level may be used as an early predictor of sepsis, MOD, and mortality in trauma population.en_US
dc.identifier.citationAl Rawahi, A. (2019). The Role of Procalcitonin Measurements in Predicting Clinical Outcomes in Critically Ill/Injured Patients (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/36748
dc.identifier.urihttp://hdl.handle.net/1880/110641
dc.language.isoengen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.subjectProcalcitoninen_US
dc.subjectTraumaen_US
dc.subjectCritical Careen_US
dc.subjectPrognosisen_US
dc.subjectOpen Abdomenen_US
dc.subjectNegative pressure peritoneal therapyen_US
dc.subjectInjuryen_US
dc.subject.classificationMedicine and Surgeryen_US
dc.titleThe Role of Procalcitonin Measurements in Predicting Clinical Outcomes in Critically Ill/Injured Patientsen_US
dc.typemaster thesisen_US
thesis.degree.disciplineMedicine – Medical Sciencesen_US
thesis.degree.grantorUniversity of Calgaryen_US
thesis.degree.nameMaster of Science (MSc)en_US
ucalgary.item.requestcopytrueen_US
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