Will the real multiple sclerosis please stand up?

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dc.contributor.authorStys, Peter K.
dc.contributor.authorZamponi, Gerald W.
dc.contributor.authorGeurts, Jeroen J. G.
dc.contributor.authorVan-Minnen, Jan
dc.date.accessioned2018-05-22T17:06:53Z
dc.date.available2018-05-22T17:06:53Z
dc.date.issued2012-06-20
dc.description.abstractMultiple sclerosis (MS) is considered to be an autoimmune, inflammatory disease of the CNS. In most patients, the disease follows a relapsing-remitting course and is characterized by dynamic inflammatory demyelinating lesions in the CNS. Although on the surface MS may appear consistent with a primary autoimmune disease, questions have been raised as to whether inflammation and/or autoimmunity are really at the root of the disease, and it has been proposed that MS might in fact be a degenerative disorder. We argue that MS may be an 'immunological convolution' between an underlying primary degenerative disorder and the host's aberrant immune response. To better understand this disease, we might need to consider non-inflammatory primary progressive MS as the 'real' MS, with inflammatory forms reflecting secondary, albeit very important, reactions.en_US
dc.identifier.citationStys, P., Zamponi, G., van Minnen, J. and Geurts, J. (2012). Will the real multiple sclerosis please stand up?. Nature Reviews Neuroscience, 13, pp.507-513. doi:10.1038/nrn3275en_US
dc.identifier.doihttp://dx.doi.org/10.1038/nrn3275en_US
dc.identifier.urihttp://hdl.handle.net/1880/106648
dc.identifier.urihttps://doi.org/10.11575/PRISM/43851
dc.language.isoenen_US
dc.publisherMacmillan Publishers Limiteden_US
dc.publisher.departmentClinical Neurosciencesen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.titleWill the real multiple sclerosis please stand up?en_US
dc.typeunknown
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