Major Depression, Antidepressant Medication and the Risk of Obesity

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dc.contributor.authorPatten, Scott B.eng
dc.contributor.authorWilliams, Jeanne V.A.eng
dc.contributor.authorLavorato, Dina H.
dc.contributor.authorBrown, Lauren
dc.contributor.authorMcLaren, Lindsay
dc.contributor.authorEliasziw, Michael
dc.date.accessioned2012-06-24T20:07:34Z
dc.date.available2012-06-24T20:07:34Z
dc.date.issued2009
dc.descriptionThis late revision is archived here in order to comply with the requirements of the funding agency.eng
dc.description.abstractBackground: Cross-sectional studies have reported an association between episodes of major depression (MDE) and obesity. The objective of this longitudinal analysis was to determine whether MDE increases the risk of becoming obese over a 10 year period. Method: We used data from the Canadian National Population Health Survey (NPHS), a longitudinal study of a representative cohort of household residents in Canada. The incidence of obesity, defined as a body mass index (BMI) of ≥ 30 kg/m2 was evaluated in respondents who were 18 years or older at the time of a baseline interview in 1994. MDE was assessed using a brief diagnostic instrument. Results: The risk of obesity was not elevated in association with MDE, either in unadjusted or covariate-adjusted analyses. The strongest predictor of obesity was a BMI in the overweight (but not obese) range. Effects were also seen for (younger) age, (female) sex, a sedentary activity pattern, low income and exposure to antidepressant medications. Unexpectedly, significant effects were seen for serotonin reuptake inhibiting antidepressants and venlafaxine, but not for tricyclic antidepressants nor antipsychotic medications. Conclusions: MDE does not appear to increase the risk of obesity. The cross-sectional associations that have been reported, albeit inconsistently, in the literature probably represent an effect of obesity on MDE risk. Pharmacologic treatment with antidepressants may be associated with an increased risk of obesity, and strategies to offset this risk may be useful in clinical practice.eng
dc.description.grantingagencyCIHReng
dc.description.refereedYeseng
dc.description.sponsorshipCanadian Institutes of Health Researcheng
dc.identifier.citationPatten SB, Williams J, Lavorato DH, Campbell N, Eliasziw M, Campbell T. Major Depression as a Risk Factor for High Blood Pressure: Epidemiologic Evidence from a National Longitudinal Study. Psychosomatic Medicine 2009; 71:273-279.eng
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33824
dc.identifier.grantnumberMOP-89816eng
dc.identifier.issn0033-3190
dc.identifier.urihttp://hdl.handle.net/1880/49061
dc.language.isoengeng
dc.publisherKargereng
dc.publisher.corporateUniversity of Calgaryeng
dc.publisher.facultyMedicineeng
dc.publisher.urlhttp://content.karger.com/ProdukteDB/produkte.asp?Aktion=JournalHome&ProduktNr=223864&ContentOnly=falseeng
dc.subjectHealth Scienceseng
dc.subjectMajor Depressive Disordereng
dc.subject.otherLongitudinal Studieseng
dc.subject.otherObesityeng
dc.titleMajor Depression, Antidepressant Medication and the Risk of Obesityeng
dc.typejournal article
thesis.degree.disciplineCommunity Health Sciences and Psychiatryeng
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