Functional Near-Infrared Spectroscopy Reveals Reduced Interhemispheric Cortical Communication after Pediatric Concussion

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dc.contributor.authorUbran, Karolina J.
dc.contributor.authorBarlow, Karen M.
dc.contributor.authorJimenez, Jon J.
dc.contributor.authorGoodyear, Bradley G.
dc.contributor.authorDunn, Jeffrey F.
dc.date.accessioned2017-03-17T22:53:35Z
dc.date.available2017-03-17T22:53:35Z
dc.date.issued2015-06-01
dc.descriptionFinal publication is available from Mary Ann Liebert, Inc., publishers http://dx.doi.org/10.1089/neu.2014.3577en_US
dc.description.abstractConcussion, or mild traumatic brain injury (mTBI), is a growing concern, especially among the pediatric population. By age 25, as many as 30% of the population are likely to have had a concussion. Many result in long-term disability, with some evolving to postconcussion syndrome. Treatments are being developed, but are difficult to assess given the lack of measures to quantitatively monitor concussion. There is no accepted quantitative imaging metric for monitoring concussion. We hypothesized that because cognitive function and fiber tracks are often impacted in concussion, interhemispheric brain communication may be impaired. We used functional near-infrared spectroscopy (fNIRS) to quantify functional coherence between the left and right motor cortex as a marker of interhemispheric communication. Studies were undertaken during the resting state and with a finger-tapping task to activate the motor cortex. Pediatric patients (ages 12–18) had symptoms for 31–473 days, compared to controls, who have not had reported a previous concussion. We detected differences between patients and controls in coherence between the contralateral motor cortices using measurements of total hemoglobin and oxy-hemoglobin with a p < 0.01 (n = 8, control; n = 12 mTBI). Given the critical need for a quantitative biomarker for recovery after a concussion, we present these data to highlight the potential of fNIRS coupled with interhemispheric coherence analysis as a biomarker of concussion injury.en_US
dc.description.grantingagencyAlberta Children’s Hospital Research Institute, the Alberta Children’s Hospital Research Foundation, the Canadian Foundation for Innovation, and the National Sciences and Engineering Research Council.en_US
dc.description.refereedYesen_US
dc.identifier.doi10.1089/neu.2014.3577
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33493
dc.identifier.issn0897-7151
dc.identifier.urihttp://hdl.handle.net/1880/51879
dc.language.isoenen_US
dc.publisherMary Ann Lieberten_US
dc.publisher.corporateUniversity of Calgary
dc.publisher.departmentRadiologyen_US
dc.publisher.facultyMedicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.subjectcoherenceen_US
dc.subjectconcussionen_US
dc.subjectfNIRSen_US
dc.subjectmild traumatic brain injuryen_US
dc.subjectnear infrared spectroscopyen_US
dc.titleFunctional Near-Infrared Spectroscopy Reveals Reduced Interhemispheric Cortical Communication after Pediatric Concussionen_US
dc.typejournal article
thesis.degree.disciplineRadiology / Physiology / Clinical Neurosciences
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