ING3 Expression in Prostate Cancer and Its Association with ERG Gene Rearrangements and Patient Outcome

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atmire.migration.oldid1938
dc.contributor.advisorBismar, Tarek
dc.contributor.advisorDemetrick, Douglas
dc.contributor.authorAlmami, Amal
dc.date.accessioned2014-02-05T21:55:34Z
dc.date.available2015-02-06T08:00:24Z
dc.date.issued2014-02-05
dc.date.submitted2014en
dc.description.abstractETS Related Gene (ERG) rearrangement is one of the most common genetic changes seen in roughly about 50% of prostate cancer (PCA) cases. The inhibitor of growth family member 3 (ING3) is a member of the ING tumor suppressor family. The deregulation of ING3 expression has been reported in various types of cancers. However, to date the role and function of ING3 in PCA as well as its relationship to ERG gene rearrangement has not been studied. Our initial observation from microarray expression profiling showed that ING3 was down-regulated in ERG positive prostate cancer samples in comparison to ERG negative tumors. In this work, we examined the expression and localization of ING3 in prostate cancer cell lines and tissue samples and its association to clinical outcome. We documented a significant association between ERG and ING3 and showed a significant association to the patients’ clinical outcome, thus highlighting a potential role for ING3 in prostate cancer progression.en_US
dc.description.embargoterms12 monthsen_US
dc.identifier.citationAlmami, A. (2014). ING3 Expression in Prostate Cancer and Its Association with ERG Gene Rearrangements and Patient Outcome (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26531en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/26531
dc.identifier.urihttp://hdl.handle.net/11023/1371
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectPathology
dc.subject.classificationProstate Canceren_US
dc.subject.classificationING3en_US
dc.subject.classificationTMPRSS2-ERG rearrangementen_US
dc.titleING3 Expression in Prostate Cancer and Its Association with ERG Gene Rearrangements and Patient Outcome
dc.typemaster thesis
thesis.degree.disciplineMedical Science
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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