Concurrent Assessment of Knee Cartilage Morphology and Bone Microarchitecture using Contrast-Enhanced HR-pQCT Imaging

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dc.contributor.advisorBoyd, Steven Kyle
dc.contributor.authorMichalak, Geoffrey Jan
dc.contributor.committeememberEdwards, William Brent
dc.contributor.committeememberWalker, Richard E. A.
dc.date2018-11
dc.date.accessioned2018-05-25T19:03:57Z
dc.date.available2018-05-25T19:03:57Z
dc.date.issued2018-05-22
dc.description.abstractOsteoarthritis (OA) is a prevalent articular disease characterized by degradation of articular cartilage and bone. Presently, no single imaging modality concurrently captures these changes. This study sought to develop and validate a novel joint imaging technique, contrast enhanced high resolution peripheral quantitative computed tomography (CEHR-pQCT), to concurrently assess bone microarchitecture and cartilage morphology. Cadaveric knees were harvested (n=10) and scanned using magnetic resonance imaging (MRI), HR-pQCT without contrast, and HR- pQCT following intra-articular injection of non-ionic contrast media. Joints were disarticulated, and the articular cartilage thickness measured by needle probe. Measures of cartilage morphology were found to be significantly different between MRI, needle probing and CEHR- pQCT. Bone microarchitecture was found to be significantly different in CEHR-pQCT, where cortical bone mineral density (BMD) was depressed, and trabecular BMD increased. This study contributes toward the advancement of whole joint imaging techniques, laying the foundation to perform in vivo scanning of knee cartilage and bone.en_US
dc.identifier.citationMichalak, G. J. (2018). Concurrent Assessment of Knee Cartilage Morphology and Bone Microarchitecture using Contrast-Enhanced HR-pQCT Imaging (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/31941en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/31941
dc.identifier.urihttp://hdl.handle.net/1880/106674
dc.language.isoeng
dc.publisher.facultyCumming School of Medicine
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectHR-pQCT
dc.subjectOsteoarthritis
dc.subjectContrast Media
dc.subjectCartilage
dc.subjectBone
dc.subjectCEHR-pQCT
dc.subject.classificationMedicine and Surgeryen_US
dc.subject.classificationRadiologyen_US
dc.subject.classificationEngineering--Biomedicalen_US
dc.titleConcurrent Assessment of Knee Cartilage Morphology and Bone Microarchitecture using Contrast-Enhanced HR-pQCT Imaging
dc.typemaster thesis
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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