The effect of sodium thiosulfate on cytotoxicity of a diimine Re(I) tricarbonyl complex

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dc.contributor.authorCapper, Miles S.
dc.contributor.authorEnriquez Garcia, Alejandra
dc.contributor.authorLai, Barry
dc.contributor.authorWang, Baiwen O.
dc.contributor.authorGelfand, Benjamin S.
dc.contributor.authorShemanko, Carrie S.
dc.contributor.authorJalilehvand, Farideh
dc.date.accessioned2021-07-30T17:18:35Z
dc.date.embargolift2022-01-16
dc.date.issued2021-04-16
dc.description.abstractRecently, diimine Re(I) tricarbonyl complexes have attracted great interest due to their promising cytotoxic effects. Here, we compare the cytotoxicity and cellular uptake of two Re(I) compounds fac-[(Re(CO)3(bpy)(H2O)](CF3SO3) (1) and Na(fac-[(Re(CO)3(bpy)(S2O3)])·H2O (bpy = 2,2?-bipyridine) (2). The Re-thiosulfate complex in 2 was characterized in two solvated crystal structures {Na(fac-[Re(CO)3(bpy)(S2O3)])·1.75H2O·C2H5OH}4 (2 + 0.75H2O + C2H5OH)4 and (fac-[Re(CO)3(bpy)(H2O)]) (fac-[Re(CO)3(bpy)(S2O3)])·4H2O (3). The cytotoxicity of 1 and 2 was tested in the MDA-MB-231 breast cancer cell line and compared with that of cisplatin. The cellular localization of the Re(I) complexes was investigated using synchrotron-based X-ray fluorescence microscopy (XFM). The results show that replacement of the aqua ligand with thiosulfate renders the complex less toxic most likely by distrupting its cellular entry. Therefore, thiosulfate could potentially have a similar chemoprotective effect against diimine fac-Re(CO)3 complexes as it has against cisplatin.
dc.description.grantingagencyNatural Science and Engineering Research Council of Canada
dc.description.grantingagencyCanadian Cancer Society
dc.description.grantingagencyCanadian Foundation for Innovation
dc.description.grantingagencyDepartment of Innovation and Science of Province of Alberta
dc.identifier.citationCapper, M. S., Enriquez Garcia, A., Lai, B., Wang, B. O., Gelfand, B. S., Shemanko, C. S., & Jalilehvand, F. (2021). The effect of sodium thiosulfate on cytotoxicity of a diimine Re(I) tricarbonyl complex. Dalton Transactions, 50(17), 5968–5977. doi:10.1039/d1dt00517k
dc.identifier.doi10.1039/D1DT00517K
dc.identifier.grantnumberRGPIN 2016-04546
dc.identifier.grantnumberRGPIN-2018-04773
dc.identifier.grantnumber#300072
dc.identifier.grantnumber#9479
dc.identifier.issn1477-9234
dc.identifier.urihttp://hdl.handle.net/1880/113675
dc.identifier.urihttps://dx.doi.org/10.11575/PRISM/39046
dc.language.isoenen
dc.language.isoeng
dc.publisherThe Royal Society of Chemistry
dc.publisher.departmentChemistry
dc.publisher.facultyScienceen
dc.publisher.hasversionPost-print
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.policyhttps://www.rsc.org/journals-books-databases/open-access/green-open-access/
dc.rightsUnless otherwise indicated, this material is protected by copyright and has been made available with authorization from the copyright owner. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en
dc.titleThe effect of sodium thiosulfate on cytotoxicity of a diimine Re(I) tricarbonyl complex
dc.typejournal article
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