A cell-permeant peptide corresponding to the cUBP domain of USP5 reverses inflammatory and neuropathic pain

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dc.contributor.authorGarcía-Caballero, Agustín
dc.contributor.authorGadotti, Vinícius Maria
dc.contributor.authorChen, Lina
dc.contributor.authorZamponi, Gerald W.
dc.date.accessioned2018-05-30T20:51:01Z
dc.date.available2018-05-30T20:51:01Z
dc.date.issued2016-01-01
dc.description.abstractCav3.2 T-type calcium currents in primary afferents are enhanced in various painful pathological conditions, whereas inhibiting Cav3.2 activity or expression offers a strategy for combating the development of pain hypersensitivity. We have shown that Cav3.2 channel surface density is strongly regulated by the ubiquitination machinery and we identified the deubiquitinase USP5 as a Cav3.2 channel interacting protein and regulator of its cell surface expression. We also reported that USP5 is upregulated in chronic pain conditions. Conversely, preventing its binding to the channel in vivo mediates analgesia in inflammatory and neuropathic pain models.en_US
dc.identifier.citationGarcia-Caballero, A., Gadotti, V. M., Chen, L., & Zamponi, G. W. (2016). A cell-permeant peptide corresponding to the cUBP domain of USP5 reverses inflammatory and neuropathic pain. Molecular Pain, 12. https://doi.org/10.1177/174480691664244en_US
dc.identifier.doihttp://dx.doi.org/10.1177/1744806916642444en_US
dc.identifier.issn1744-8069
dc.identifier.urihttp://hdl.handle.net/1880/106720
dc.identifier.urihttps://doi.org/10.11575/PRISM/43862
dc.language.isoenen_US
dc.publisherSage Publishingen_US
dc.publisher.departmentPhysiology & Pharmacologyen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.publisher.policyhttps://us.sagepub.com/en-us/nam/journals-permissionsen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.subjectT-type channelsen_US
dc.subjectCav3.2en_US
dc.subjectUSP5en_US
dc.subjectchronic painen_US
dc.subjectTAT-cUBP1-USP5 peptideen_US
dc.subjectdiabetic neuropathyen_US
dc.subjectComplete Freund's Adjuvanten_US
dc.titleA cell-permeant peptide corresponding to the cUBP domain of USP5 reverses inflammatory and neuropathic painen_US
dc.typejournal articleen_US
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