Ischemia-Reperfusion Arrhythmias and Intercellular Coupling in Diabetic and Ischemic-Preconditioned Rat Heart

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dc.contributor.advisorNygren, Anders
dc.contributor.authorRandall, Alyssa
dc.date.accessioned2013-01-30T16:45:41Z
dc.date.available2013-06-15T07:01:48Z
dc.date.issued2013-01-30
dc.date.submitted2013en
dc.description.abstractDiabetes and Ischemic Preconditioning (IPC) have been shown in literature to have similar metabolic and microscopic effects on intercellular coupling, conduction reserve, and the response to ischemia-reperfusion in ventricular tissue. Both diabetes and IPC cause reduced intercellular coupling; reduced conduction reserve; and provide cardio-protection to ischemia/reperfusion. To determine the whole heart similarities between IPC and diabetes both electrocardiograph (ECG) and optical mapping data was evaluated. Diabetes displayed different time dependent responses to ischemia/reperfusion from IPC and healthy animals; diabetic animals slow heart rate significantly compared to IPC and control animals during ischemia, while IPC slows conduction velocity. During pacing, IPC and diabetic animals showed similar slowing of conduction velocity though only diabetic animals showed significant slowing in response to reduced cellular excitability. This work suggests IPC and diabetes do not use the same mechanisms to provide cardio-protective effects.en_US
dc.identifier.citationRandall, A. (2013). Ischemia-Reperfusion Arrhythmias and Intercellular Coupling in Diabetic and Ischemic-Preconditioned Rat Heart (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26676en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/26676
dc.identifier.urihttp://hdl.handle.net/11023/534
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectAnimal Physiology
dc.subjectEngineering--Biomedical
dc.subjectEngineering--Electronics and Electrical
dc.subject.classificationIschemiaen_US
dc.subject.classificationresperfusionen_US
dc.subject.classificationDiabetesen_US
dc.subject.classificationarrhythmiaen_US
dc.subject.classificationischemic preconditioningen_US
dc.titleIschemia-Reperfusion Arrhythmias and Intercellular Coupling in Diabetic and Ischemic-Preconditioned Rat Heart
dc.typemaster thesis
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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