Mesenchymal Stem Cell Therapy for Ischemic Tissues

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dc.contributor.authorYong, Kar Wey
dc.contributor.authorChoi, Jane Ru
dc.contributor.authorMohammadi, Mehdi
dc.contributor.authorMitha, Alim P.
dc.contributor.authorSanati-Nezhad, Amir
dc.contributor.authorSen, Arindom
dc.date.accessioned2018-10-14T07:02:57Z
dc.date.available2018-10-14T07:02:57Z
dc.date.issued2018-10-08
dc.date.updated2018-10-14T07:02:56Z
dc.description.abstractIschemic diseases such as myocardial infarction, ischemic stroke, and critical limb ischemia are immense public health challenges. Current pharmacotherapy and surgical approaches are insufficient to completely heal ischemic diseases and are associated with a considerable risk of adverse effects. Alternatively, human mesenchymal stem cells (hMSCs) have been shown to exhibit immunomodulation, angiogenesis, and paracrine secretion of bioactive factors that can attenuate inflammation and promote tissue regeneration, making them a promising cell source for ischemic disease therapy. This review summarizes the pathogenesis of ischemic diseases, discusses the potential therapeutic effects and mechanisms of hMSCs for these diseases, and provides an overview of challenges of using hMSCs clinically for treating ischemic diseases.
dc.description.versionPeer Reviewed
dc.identifier.citationKar Wey Yong, Jane Ru Choi, Mehdi Mohammadi, Alim P. Mitha, Amir Sanati-Nezhad, and Arindom Sen, “Mesenchymal Stem Cell Therapy for Ischemic Tissues,” Stem Cells International, vol. 2018, Article ID 8179075, 11 pages, 2018. doi:10.1155/2018/8179075
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33207
dc.identifier.urihttp://dx.doi.org/10.1155/2018/8179075
dc.identifier.urihttp://hdl.handle.net/1880/108885
dc.language.rfc3066en
dc.rights.holderCopyright © 2018 Kar Wey Yong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleMesenchymal Stem Cell Therapy for Ischemic Tissues
dc.typeJournal Article
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