Browsing by Author "Nakanishi, Nobuki"

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    Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits
    (Society for Neuroscience, 2010-08-25) PiƱa-Crespo, Juan C.; Talantova, Maria V.; Micu, Ileana; States, Bradley A.; Chen, Huei Sheng Vincent; Tu, Shichun; Nakanishi, Nobuki; Tong, Gary G.; Zhang, Dongxian; Heinemann, Stephen F.; Zamponi, Gerald W.; Stys, Peter K.; Lipton, Stuart A.
    NMDA receptors are typically excited by a combination of glutamate and glycine. Here we describe excitatory responses in CNS myelin that are gated by a glycine agonist alone and mediated by NR1/NR3 "NMDA" receptor subunits. Response properties include activation by d-serine, inhibition by the glycine-site antagonist CNQX, and insensitivity to the glutamate-site antagonist d-APV. d-Serine responses were abrogated in NR3A-deficient mice. Our results suggest the presence of functional NR1/NR3 receptors in CNS myelin.