Multiple sclerosis disease progression: Contributions from a hypoxia–inflammation cycle.
Date
2018-07-08
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
SAGE Publications
Abstract
Hypoxia has been associated with multiple sclerosis (MS) and is an important area of research. Hypoxia can exacerbate inflammation via the prolylhydroxylase pathway. Inflammation can also trigger hypoxia by damaging mitochondria and endothelial cells to impair blood flow regulation. We hypothesize that there is a “hypoxia–inflammation cycle” in MS which plays an important role in MS disease progression. Therapies that break this cycle may be an interesting area of exploration for treatment of MS.
Description
Keywords
Biomarkers, hypoxia, inflammation
Citation
Yang, R., & Dunn, J. F. (2018). Multiple sclerosis disease progression: Contributions from a hypoxia–inflammation cycle. Multiple Sclerosis Journal. https://doi.org/10.1177/1352458518791683