Multiple sclerosis disease progression: Contributions from a hypoxia–inflammation cycle.

Yang, Runze; Dunn, Jeff F.

Multiple sclerosis disease progression: Contributions from a hypoxia–inflammation cycle.

dc.contributor.author	Yang, Runze
dc.contributor.author	Dunn, Jeff F.
dc.date.accessioned	2018-10-25T15:35:41Z
dc.date.available	2018-10-25T15:35:41Z
dc.date.issued	2018-07-08
dc.description.abstract	Hypoxia has been associated with multiple sclerosis (MS) and is an important area of research. Hypoxia can exacerbate inflammation via the prolylhydroxylase pathway. Inflammation can also trigger hypoxia by damaging mitochondria and endothelial cells to impair blood flow regulation. We hypothesize that there is a “hypoxia–inflammation cycle” in MS which plays an important role in MS disease progression. Therapies that break this cycle may be an interesting area of exploration for treatment of MS.	en_US
dc.description.grantingagency	Alberta Innovates - Research Grant	en_US
dc.identifier.citation	Yang, R., & Dunn, J. F. (2018). Multiple sclerosis disease progression: Contributions from a hypoxia–inflammation cycle. Multiple Sclerosis Journal. https://doi.org/10.1177/1352458518791683	en_US
dc.identifier.doi	10.1177/1352458518791683	en_US
dc.identifier.doi	http://dx.doi.org/10.11575/PRISM/33894
dc.identifier.issn	1352-4585
dc.identifier.uri	http://hdl.handle.net/1880/108913
dc.language.iso	en	en_US
dc.publisher	SAGE Publications	en_US
dc.publisher.department	Radiology	en_US
dc.publisher.faculty	Cumming School of Medicine	en_US
dc.publisher.policy	http://www.sherpa.ac.uk/romeo/issn/1352-4585/	en_US
dc.rights.uri	https://creativecommons.org/licenses/by/4.0	en_US
dc.subject	Biomarkers	en_US
dc.subject	hypoxia	en_US
dc.subject	inflammation	en_US
dc.title	Multiple sclerosis disease progression: Contributions from a hypoxia–inflammation cycle.	en_US
dc.type	journal article	en_US