Monitoring angiogenesis using a human compatible calibration for broadband near-infrared spectroscopy

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dc.contributor.authorYang, Runze
dc.contributor.authorZhang, Qiong
dc.contributor.authorWu, Ying
dc.contributor.authorDunn, Jeffery F.
dc.date.accessioned2017-03-13T22:06:25Z
dc.date.available2017-03-13T22:06:25Z
dc.date.issued2013-01
dc.description.abstractAngiogenesis is a hallmark of many conditions, including cancer, stroke, vascular disease, diabetes, and high-altitude exposure. We have previously shown that one can study angiogenesis in animal models by using total hemoglobin (tHb) as a marker of cerebral blood volume (CBV), measured using broadband near-infrared spectroscopy (bNIRS). However, the method was not suitable for patients as global anoxia was used for the calibration. Here we determine if angiogenesis could be detected using a calibration method that could be applied to patients. CBV, as a marker of angiogenesis, is quantified in a rat cortex before and after hypoxia acclimation. Rats are acclimated at 370-mmHg pressure for three weeks, while rats in the control group are housed under the same conditions, but under normal pressure. CBV increased in each animal in the acclimation group. The mean CBV (%volumeāˆ•volume) is 3.49% 0.43% (mean SD) before acclimation for the experimental group, and 4.76% 0.29% after acclimation. The CBV for the control group is 3.28% 0.75%, and 3.09% 0.48% for the two measurements. This demonstrates that angiogenesis can be monitored noninvasively over time using a bNIRS system with a calibration method that is compatible with human use and less stressful for studies using animals.en_US
dc.description.grantingagencyNIH, Canadian Institutes of Health Research, Canadian Foundation for Innovation and the Alberta Innovates Health Solutionsen_US
dc.description.refereedYesen_US
dc.identifier.citationYang R. et. al. (2013). Monitoring angiogenesis using a human compatible calibration for broadband near-infrared spectroscopy. Journal of Biomedical Optics. 18(1): 016011en_US
dc.identifier.doi10.1117/1.JBO.18.1.016011
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33518
dc.identifier.grantnumberRO1 EB002085, FIN 79260en_US
dc.identifier.issn1083-3668
dc.identifier.urihttp://hdl.handle.net/1880/51856
dc.language.isoenen_US
dc.publisherSociety of Photo-optical Instrumentation Engineers (SPIE)en_US
dc.publisher.corporateUniversity of Calgary
dc.publisher.departmentRadiologyen_US
dc.publisher.facultyMedicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.subjectnear-infrared spectroscopyen_US
dc.subjectnear infrareden_US
dc.subjecthemoglobinen_US
dc.subjectacclimationen_US
dc.subjectcerebral blood volumeen_US
dc.subjectangiogenesisen_US
dc.subjecthypoxiaen_US
dc.subjectbrainen_US
dc.titleMonitoring angiogenesis using a human compatible calibration for broadband near-infrared spectroscopyen_US
dc.typejournal article
thesis.degree.disciplineRadiology / Physiology / Clinical Neurosciences
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