Impact of Growth Hormone on Adult Bone Quality in Turner Syndrome - A High Resolution Peripheral Quantitative Computed Tomography Study
Date
2014-02-03
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Caused by total or partial X-monosomy, Turner Syndrome (TS) is the most common
chromosomal disorder in females. Commonly associated features include short stature,
ovarian failure and osteoporosis in adult years. Childhood short-stature in TS is commonly
treated with growth hormone (GH).
This historic cohort-study using dual x-ray absorptiometry (DXA) and high resolution
peripheral quantitative computed tomography (HR-pQCT) was conducted to determine the
effect of childhood GH treatment on adult bone quality in TS women. Karyotype confirmed
TS women aged 16-45 years were recruited (N=28). GH-treated subjects were 7.4 cm taller
than non-GH-treated (p<0.05). Groups were similar in regard to known bone health risk
factors. GH-treated subjects had significantly larger bone areas (9-25%, p<0.05) by DXA
and HR-pQCT. Bone densities, micro-architecture and estimated fracture thresholds were
not different among treatment groups.
While no micro-architectural benefits were observed with GH-treatment, the
persistent macro-structural differences may provide advantages in future fracture risk.
Description
Keywords
Medicine and Surgery
Citation
Nour, M. A. (2014). Impact of Growth Hormone on Adult Bone Quality in Turner Syndrome - A High Resolution Peripheral Quantitative Computed Tomography Study (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26456